Comparison of QT interval in neonates with maternal gestational diabetes and healthy mothers

Abstract

Background: The risk of developing metabolic syndrome and diseases as Diabetes mellitus have been raised as worldwide rise of obesity. Gestational diabetes (GDM) or maternal hyperglycemia is a risk factor for cardiac dysfunction in neonates. The present study compared QT interval in neonates with maternal gestational diabetes and healthy mothers.Patients and Methods: In this case-control study, term neonates with maternal GDM (case group, N = 42) and those with healthy non-diabetic mothers (control group, N=42) have been included from March 2016 to February 2017, in Sayyad-e-Shirazi hospital, Gorgan, Northeast of Iran. A pediatric cardiologist evaluated septal hypertrophy by Doppler echocardiography (Zonare ZS3) during first two weeks after birth. A standard 12-lead electrocardiogram was recorded for 10 seconds and corrected QT (QTc) value was calculated. Data were analyzed in latest version of SPSS using Chi-square and t-test to evaluate the differences in QT values and other indices between two groups. P-values less than 0.05 were considered statistically significant.Results: The present study showed congenital heart diseases in 6 neonates. Significantly higher QT (249±36 vs. 245± 28 ms) and septal thickness (6.09±1.07 vs. 5± 1 mm) and lower QTc value (382±44.06 vs. 392± 34 ms) were seen in case group compared to controls (P