Effects of Psychopharmacologic Agents on Experimentally-Induced Seizures in Mice*

Abstract

Of seven psychopharmacologic drugs screened by five assay procedures, only meprobamate ana phenaglycodol exhibited significant anticonvulsant activity. Chlorpromazine, promazine, reserpine, and hydroxyzine lowered the threshold for minimal seizures variously induced, whereas triflupromazine had no effect on seizure threshold. The data obtained correlate well with available clinical data and indicate the value of threshold seizure studies in animals for detecting agents which may cause convulsions in man.