Health and performance outcomes from a randomized clinical trial of post-metaphylactic intervals following tildipirosin metaphylaxis for control of naturally occurring BRD in commingled lightweight yearling steers in a commercial feedlot

John I. Szasz, T. Bryant, L. Bryant, M. Streeter, J. Hutcheson, D. Renter
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Abstract

This study’s objectives were to assess health and performance outcomes in yearling steers randomized to pens with 4-day, 7-day, 10-day, or 13-day postmetaphylaxis intervals (PMI) following arrival administration of tildipirosin (ZuprevoR). The primary objective was to assess linear or non-linear responses to different PMI. Crossbred beef steers (N = 8,160), 648 lb overall mean body weight, were allocated to 40 pens, in 10 blocks, over a 3-week period. Study blocks were defined by arrival and processing date. Data were analyzed using mixed models for a randomized complete block design with pen as the experimental unit. Across all pens and blocks, the incidence of BRD first pulls, morbidity (temperature > 103.5°F), mortality, and removals were: 11.67%, 9.20%, 0.89% and 0.92%, respectively. During the first 45 days, there were linear relationships between PMI and BRD morbidity (P = 0.006) and BRD first pulls (P = 0.003) indicating that apparent incidence decreased linearly as PMI increased. Over the entire feeding period (mean = 217 days), apparent BRD morbidity also decreased linearly (P = 0.01) as PMI increased; however, there was a quadratic (non-linear) relationship between BRD first pulls and PMI (group means 12.0%, 12.9%, 11.08% and 9.49%, respectively). There were no significant associations (P values > 0.10) between PMI and BRD relapses, first treatment success, case fatality, mortality or any live and carcass performance measures. In this study, longer PMI (fewer days eligible for treatment) led to reduced BRD first treatments, with no evidence for negative impacts on mortality or performance.
一项随机临床试验的健康和性能结果:在商业饲养场进行替地匹罗辛过敏反应后的变态反应间隔,以控制天然发生的BRD
本研究的目的是评估在给药替地匹罗欣(ZuprevoR)后,随机分为4天、7天、10天或13天过敏反应后间隔(PMI)的一岁阉牛的健康和性能结果。主要目的是评估对不同PMI的线性或非线性反应。杂交肉牛(N = 8,160),总平均体重648磅,在3周的时间内被分配到10个街区的40个栏中。研究块由到达和处理日期定义。以笔为实验单元,采用随机完全块设计的混合模型分析数据。在所有围栏和小区中,BRD首次拔鼠的发病率、发病率(温度> 103.5°F)、死亡率和清除率分别为11.67%、9.20%、0.89%和0.92%。在前45天,PMI与BRD发病率呈线性关系(P = 0.006), BRD首次拉伤(P = 0.003)表明表观发病率随着PMI的增加呈线性下降。在整个饲养期内(平均217天),随着PMI的增加,BRD的表观发病率呈线性下降(P = 0.01);然而,BRD首次拉动与PMI之间存在二次(非线性)关系(组均值分别为12.0%、12.9%、11.08%和9.49%)。PMI与BRD复发、首次治疗成功、病死率、死亡率或任何活产和胴体性能指标之间没有显著相关性(P值> 0.10)。在这项研究中,更长的PMI(更少的治疗天数)导致BRD首次治疗减少,没有证据表明对死亡率或表现有负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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