Kinesin-1 Traffic Control in Neuronal Highway

Abstract

Context: The current study aimed to review research articles concerning kinesin-1 traffic control in the neuronal highways Evidence Acquisition: This review article compromised previous studies published since 1980 using PubMed, Google scholar, Embase, Medline, science direct and SID databases according to the keywords. Results: Kinesin-1 often recognizes scaffold proteins or adaptor proteins and binds to cargo membrane proteins directly as part of a protein complex. Several kinases and microtubule associated proteins are identified in the regulation of motor-cargo unloading. The mechanisms by which kinesin-1 recognizes and binds to specific cargos, and how to unload cargo and determine the direction of transport, are now identified. Conclusions: In summary, the current review article demonstrated that some proteins such as adaptors, Scaffolds, chaperons and microtubule associated proteins and some metabolites, hormones, protein kinases and exercise training can regulate kinesin-1 traffic control in neuronal highway. These findings open exciting new areas of kinesin-1 research. Keywords: Kinesin-1, Scaffold Proteins, Adaptor Proteins, Neuronal Transport