Reply: Single-Time-Point Tumor Dosimetry Assuming Normal Distribution of Tumor Kinetics.

IF 1.7 4区 工程技术 Q3 CHEMISTRY, APPLIED
Propellants, Explosives, Pyrotechnics Pub Date : 2022-05-01 Epub Date: 2022-03-10 DOI:10.2967/jnumed.121.263717
George Sgouros, Yuni K Dewaraja, Freddy Escorcia, Stephen A Graves, Thomas A Hope, Amir Iravani, Neeta Pandit-Taskar, Babak Saboury, Sara St James, Pat B Zanzonico
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引用次数: 0
回复:假定肿瘤动力学呈正态分布的单时间点肿瘤剂量测定。
回复:我们感谢高博士仔细阅读我们的文章(1),并阐述了单时间点成像在实际实施放射药物治疗患者特异性剂量测定中的价值。我们选择关注基本的已知和未知,特别是肿瘤剂量-反应关系,而不是解决公认的具有挑战性的患者特异性剂量测定的后勤问题。正如高博士在信中所指出的那样,单时间点配方可以应用于正常器官和肿瘤吸收剂量,尽管由于肿瘤动力学的潜在较大变异性,应用于肿瘤可能会有较大的误差。然而,取决于肿瘤大小的肿瘤活动性量化步骤中的误差可能主导剂量计算中的不确定性。总的来说,与单时间点方法相关的不确定性不太可能在临床上产生影响。临床经验表明,需要肿瘤吸收剂量的几倍差异来克服肿瘤放射敏感性、肿瘤内剂量分布、剂量率差异和其他影响肿瘤对患者治疗反应的生物学效应的影响。认识到实现适当平衡的必要性,我们将推广一种方法,使治疗医生在确定治疗剂量时,能够考虑吸收剂量准确性、卫生经济学、繁忙诊所的挑战和疾病的临床方面的多方面权衡。通过定义所有计算的吸收剂量值的确定性或不确定性水平,包括通过减少时间点或单时间点方法获得的吸收剂量值,为治疗医生提供了为特定患者做出最终临床决策所需的信息。如果根据疾病的程度和要达到的终点,医生希望在正常器官和肿瘤吸收剂量估计中获得更大的精确度,则可以与医学物理学家一起设计一个扩展的多时间点成像方案。令人鼓舞的是,除了信中描述的工作外,最近还研究了与使用多个时间点相比,使用单个成像时间点的准确性损失。在这一领域不断增长的论文列表中,我们注意到Madsen等人(2)和H€anscheid等人(3)关于肽受体放射性核素治疗的早期工作,以及Hou等人(4)和Jackson等人(5)最近将这种方法扩展到其他RPTs。Kao和《核医学杂志》主编给了我们讨论这个重要话题的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Propellants, Explosives, Pyrotechnics
Propellants, Explosives, Pyrotechnics 工程技术-工程:化工
CiteScore
4.20
自引率
16.70%
发文量
235
审稿时长
2.7 months
期刊介绍: Propellants, Explosives, Pyrotechnics (PEP) is an international, peer-reviewed journal containing Full Papers, Short Communications, critical Reviews, as well as details of forthcoming meetings and book reviews concerned with the research, development and production in relation to propellants, explosives, and pyrotechnics for all applications. Being the official journal of the International Pyrotechnics Society, PEP is a vital medium and the state-of-the-art forum for the exchange of science and technology in energetic materials. PEP is published 12 times a year. PEP is devoted to advancing the science, technology and engineering elements in the storage and manipulation of chemical energy, specifically in propellants, explosives and pyrotechnics. Articles should provide scientific context, articulate impact, and be generally applicable to the energetic materials and wider scientific community. PEP is not a defense journal and does not feature the weaponization of materials and related systems or include information that would aid in the development or utilization of improvised explosive systems, e.g., synthesis routes to terrorist explosives.
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