{"title":"Prolonged-release oxycodone/naloxone for chronic pain","authors":"Nicola O'Connell, Karen H Simpson FRCA, FFPMRCA","doi":"10.1002/fps.43","DOIUrl":null,"url":null,"abstract":"<p>Chronic pain is common, and opioid therapy is often required for pain management. Unfortunately, opioid-induced bowel dysfunction (OIBD) is a frequent and debilitating side-effect of opioid use. A new prolonged-release (PR) preparation of oxycodone/naloxone has been developed for moderate-to-severe pain that reduces OIBD in patients. In this article, we consider the mode of action and efficacy of this combination opioid therapy for chronic pain. Copyright © 2009 John Wiley & Sons, Ltd.</p>","PeriodicalId":100566,"journal":{"name":"Future Prescriber","volume":"10 1","pages":"16-19"},"PeriodicalIF":0.0000,"publicationDate":"2009-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/fps.43","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Prescriber","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/fps.43","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Chronic pain is common, and opioid therapy is often required for pain management. Unfortunately, opioid-induced bowel dysfunction (OIBD) is a frequent and debilitating side-effect of opioid use. A new prolonged-release (PR) preparation of oxycodone/naloxone has been developed for moderate-to-severe pain that reduces OIBD in patients. In this article, we consider the mode of action and efficacy of this combination opioid therapy for chronic pain. Copyright © 2009 John Wiley & Sons, Ltd.
缓释羟考酮/纳洛酮治疗慢性疼痛
慢性疼痛很常见，通常需要阿片类药物治疗来控制疼痛。不幸的是，阿片类药物引起的肠功能障碍(OIBD)是阿片类药物使用的常见和衰弱的副作用。一种新的缓释制剂羟考酮/纳洛酮已被开发用于减轻患者的OIBD的中重度疼痛。在这篇文章中，我们考虑这种联合阿片类药物治疗慢性疼痛的作用模式和疗效。版权所有©2009 John Wiley &儿子,有限公司
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