Synthesis and cytotoxicity of indolin-2-one derivatives against WiDr cells

Abstract

The synthesis of indolin-2-one derivatives and in vitro anticancer activity on colon cancer were reported in the present study. The compounds contain a fluorine or a bromine in position 5, and a bromine in position 7. The results established that indolin-2-one with bromine in position 5 gave up to a 4-fold improved cytotoxicity over indolin-2-one with fluorine in position 5. The indolein-2-one with bromine in posititon 5 also exerted higher cytotoxicity compared to bromine in position 7. This work highlights the importance of halogen and their position in cytotoxicity.