A Variety of Candida Proteinases and their Possible Targets of Proteolytic Attack in the Host

Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious... Pub Date : 1984-07-01 DOI:10.1016/S0174-3031(84)80081-5

R. Rüchel

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引用次数: 65

Abstract

Acid proteinases are secreted by the majority of strains of Candida albicans, C. tropicalis and C. parapsilosis, reflecting the sequence of virulence of Candida spp. for man. As revealed by exposure to various substrates and inhibitors, Candida proteinases are strainspecific, although close relationships exist between enzymes from strains of the same species. Possible targets of hydrolytic attack by Candida proteinases in the host are immunoglobulins, the proteinase scavenger alpha-2-macroglobulin, zymogens of regulatory serine proteinases such as coagulation factor X, and angiotensinogen. The involvement of Candida proteinase in the pathogenesis of acronecrosis is discussed.

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多种念珠菌蛋白酶及其可能的宿主蛋白酶攻击靶点

酸性蛋白酶由大多数白色念珠菌、热带念珠菌和副psilosis菌株分泌，反映了念珠菌对人类的毒力序列。暴露于各种底物和抑制剂表明，念珠菌蛋白酶是菌株特异性的，尽管同一物种菌株的酶之间存在密切关系。念珠菌蛋白酶在宿主中水解攻击的可能靶点是免疫球蛋白、蛋白酶清除剂α-2-巨球蛋白、调节丝氨酸蛋白酶的酶原如凝血因子X和血管紧张素原。讨论了念珠菌蛋白酶在肢端坏死发病机制中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...

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