Drug delivery behavior of titania nanotube arrays coated with chitosan polymer

Abstract

Titania nanotube (TNT) arrays with the length to diameter ratio of 85:1 were synthetized after anodizing the specimens at the anodizing voltage of 55 V for 2 h. Ultrasonic cleaning procedure in deionized water caused the formation of micro-cracks, clusters of TNT bundles and distortion of the nanotubes; however, acetone medium decreased the risk of fracture and the formation of clusters. To control the drug delivery rate, chitosan polymer was deposited on the surface of TNTs using dip-coating process. The total release of TNTs with 0, 0.29 and 0.45 μm chitosan coating thickness was about 6, 8 and 12 days, respectively.