Association of shift work with oxidative stress and alteration of fasting plasma glucose level in Chinese adults

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2023-09-19 DOI:10.1002/oby.23845

Wenzhen Li, Xiaobing Feng, Haozhe Zhang, Yi-Xin Wang, Qiang Zeng, Chong Liu, Victor W. Zhong, Dongming Wang

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引用次数: 0

Abstract

Objective

This study aimed to assess the association of shift work with blood glucose and the mediating role of oxidative stress.

Methods

Fasting plasma glucose (FPG) and urinary concentrations of oxidative stress biomarkers (8-hydroxy-2'-deoxyguanosine [8-OHdG], 4-hydroxy-2-nonenal-mercapturic acid, and 8-iso-prostaglandin F_2α [8-isoPGF_2α]) were measured among 831 participants.

Results

Positive dose-response relationships among shift work duration, FPG (p_trend < 0.001), and abnormal glucose regulation (AGR; p_trend = 0.035) were found. Compared with participants without shift work, three-shift work was associated with a higher level of FPG (percentage change: 6.49%, 95% CI: 4.21%–8.83%) and a higher prevalence of impaired fasting glucose (odds ratio: 1.886, 95% CI: 1.114–3.192) and AGR (odds ratio: 1.929, 95% CI: 1.197–3.111). A dose-response relationship was found between shift work duration and 8-OHdG (p_trend = 0.002) and 8-isoPGF_2α (p_trend = 0.019). Urinary 8-OHdG and 8-isoPGF_2α partially mediated the association between shift work duration and FPG levels and the prevalence of impaired fasting glucose and AGR, with mediating proportions ranging from 4.77% to 20.76%.

Conclusions

These findings suggest that shift work is positively associated with blood glucose, and the association is partially mediated by oxidative stress.

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中国成年人轮班工作与氧化应激和空腹血糖水平改变的关系

目的探讨倒班工作对血糖的影响及氧化应激的介导作用。方法测定831名受试者的空腹血糖(FPG)和尿中氧化应激生物标志物(8-羟基-2′-脱氧鸟苷[8-OHdG]、4-羟基-2-烯醛-巯基酸和8-异前列腺素F2α [8-isoPGF2α])浓度。结果倒班时长、FPG (ptrend < 0.001)和血糖调节异常(AGR;p趋势= 0.035)。与没有轮班工作的参与者相比，三班工作与更高水平的FPG(百分比变化:6.49%，95% CI: 4.21%-8.83%)和更高的空腹血糖受损患病率(优势比:1.886,95% CI: 1.114-3.192)和AGR(优势比:1.929,95% CI: 1.197-3.111)相关。轮班时长与8-OHdG (ptrend = 0.002)和8-isoPGF2α (ptrend = 0.019)呈剂量-效应关系。尿8-OHdG和8-isoPGF2α部分介导了轮班工作时长、FPG水平与空腹血糖和AGR受损患病率之间的关联，介导比例在4.77%至20.76%之间。结论:倒班工作与血糖呈正相关，部分与氧化应激有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.