Cross talk about the role of Neuropeptide Y in CNS disorders and diseases

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2023-10-24 DOI:10.1016/j.npep.2023.102388

Rajeshwari Bale, Gaurav Doshi

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Abstract

A peptide composed of a 36 amino acid called Neuropeptide Y (NPY) is employed in a variety of physiological processes to manage and treat conditions affecting the endocrine, circulatory, respiratory, digestive, and neurological systems. NPY naturally binds to G-protein coupled receptors, activating the Y-receptors (Y1-Y5 and y6). The findings on numerous therapeutic applications of NPY for CNS disease are presented in this review by the authors. New targets for treating diseases will be revealed by medication combinations that target NPY and its receptors. This review is mainly focused on disorders such as anxiety, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Machado Joseph disease, multiple sclerosis, schizophrenia, depression, migraine, alcohol use disorder, and substance use disorder. The findings from the preclinical studies and clinical studies covered in this article may help create efficient therapeutic plans to treat neurological conditions on the one hand and psychiatric disorders on the other. They may also open the door to the creation of novel NPY receptor ligands as medications to treat these conditions.

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交叉谈论神经肽Y在中枢神经系统疾病中的作用。

一种由36个氨基酸组成的肽，称为神经肽Y（NPY），用于各种生理过程，以管理和治疗影响内分泌、循环、呼吸、消化和神经系统的疾病。NPY与G蛋白偶联受体自然结合，激活Y受体（Y1-Y5和y6）。作者在这篇综述中介绍了NPY在中枢神经系统疾病治疗中的许多应用。靶向NPY及其受体的药物组合将揭示治疗疾病的新靶点。这篇综述主要集中在焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、马查多-约瑟夫病、多发性硬化症、精神分裂症、抑郁症、偏头痛、酒精使用障碍和物质使用障碍等疾病上。本文涵盖的临床前研究和临床研究结果可能有助于制定有效的治疗计划，一方面治疗神经疾病，另一方面治疗精神疾病。它们也可能为创造新的NPY受体配体作为治疗这些疾病的药物打开大门。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.