Alterations of the Apoptosis Genes and Their Products in Non-small Cell Lung Cancer Tissues

N. Yoo, S. Lee
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Abstract

Apoptosis is a principal type of cell death, and it has a profound effect on the development of cancer. It is also well known that anti-cancer agents induce apoptosis, and defects in the apoptosis pathways reduce the treatment sensitivity. Of the many pathways that induce apoptosis, the mechanisms of the intrinsic and extrinsic apoptosis pathways are well established. Non-small cell lung cancer (NSCLC) is a leading cause of cancer death worldwide, yet the exact molecular mechanisms of its development remain unclear. Apoptosis deregulations may underlie the development and pathogenesis of NSCLC. This review discusses the general mechanisms of apoptosis, the constituents of the apoptosis machinery and the alterations of the apoptosis-related genes in NSCLC. (J Lung Cancer 2008;7(2):59�� 64)
非小细胞肺癌组织中凋亡基因及其产物的改变
细胞凋亡是细胞死亡的一种主要形式,它对癌症的发生发展有着深远的影响。众所周知,抗癌药物会诱导细胞凋亡,而细胞凋亡通路的缺陷会降低治疗的敏感性。在诱导细胞凋亡的多种途径中,内源性和外源性细胞凋亡途径的机制已经确立。非小细胞肺癌(NSCLC)是世界范围内癌症死亡的主要原因,但其发展的确切分子机制尚不清楚。细胞凋亡失调可能是非小细胞肺癌发生发展和发病的基础。本文就非小细胞肺癌细胞凋亡的一般机制、细胞凋亡机制的组成及细胞凋亡相关基因的改变进行综述。[J] .肺癌杂志2008;7(2):59 - 64。
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