Bladder Cancer in Young Patients: Management and Outcomes

C. Kamadjou, D. Eyongeta, A. Kameni, A. Mbassi, F. Angwafor
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Abstract

Background and Objective: Bladder cancer frequently occurs between the ages of 50 years and 70 years and rarely occurs before the age of 40 years. It accounts for 1% - 4% of all cases of cancer. This study focuses on the clinical, etiological, histological, therapeutic, and evolutive profiles of patients with bladder cancer aged less than 45 years. Materials and Methods: This retrospective study was carried out over seven years (from January 2014 to December 2020) on 15 patients below 45 years of age who were being treated for bladder cancer. The diagnosis was made in all patients via cystoscopy and abdominal computerized tomography, while the nature, grade, and degree of infiltration were determined via endoscopic resection and pathology. Results: The mean age of the 15 patients in this study was 34.4 ± 5.19 years. In 86.6% of cases, the patients had macroscopic hematuria as the main presenting complaint. Twelve patients (80%) had bladder tumors that did not infiltrate the muscle. These patients were followed up clinically. In 86.6% of cases, there was a single tumor with a mean diameter of 2.53 cm. In four patients (26.6%), mitomycin was started early. The overall rates of tumor recurrence and progression were 26.6% and 20%, respectively. Conclusion: Bladder cancer also occurs in young people, with similar clinical and epidemiological profiles as exists in elderly patients. The prognosis of bladder cancer in young people depends on the treatment method chosen by the physician.
年轻患者膀胱癌:管理和结果
背景与目的:膀胱癌多发生在50 ~ 70岁之间,40岁以前很少发生。它占所有癌症病例的1% - 4%。本研究的重点是年龄小于45岁的膀胱癌患者的临床、病因、组织学、治疗和进化概况。材料与方法:本回顾性研究从2014年1月至2020年12月,对15例45岁以下的膀胱癌患者进行了为期7年的回顾性研究。所有患者均通过膀胱镜检查和腹部计算机断层扫描进行诊断,并通过内镜切除和病理确定浸润的性质、分级和程度。结果:本组15例患者平均年龄34.4±5.19岁。86.6%的患者以肉眼可见的血尿为主要主诉。12例患者(80%)膀胱肿瘤未浸润肌肉。对这些患者进行临床随访。86.6%的病例为单发肿瘤,平均直径2.53 cm。4例患者(26.6%)早期开始使用丝裂霉素。肿瘤复发率和进展率分别为26.6%和20%。结论:膀胱癌在年轻人中也有发生,其临床和流行病学特征与老年患者相似。年轻人膀胱癌的预后取决于医生选择的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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