The RNA interference

中国病理生理杂志 Pub Date : 1900-01-01 DOI:10.5772/60631

Kong Xiangping, Pla Air

引用次数: 2

Abstract

The phenomenon of RNA interference (RNAi) is highly conserved mechanism in the organism evolution. As a immune system ,RNAi is a ubiquitous mechanism against invading microorganism in plant and animal cells. Recently, it has been found that RNAi is the process by which double-strand RNA(dsRNA) directs sequence-specific degradation of messenger RNA and the mediations of sequence specific messenger RNA degradation are 21-and 23-nucleotide small interfering RNAs that generate by ribonuclease from endogenous longer dsRNA or by transfectious technics from heterologous dsRNA. Over the past few years, the way in which cells respond to dsRNA by silencing homologous genes has revealed a new regulating paradigm in biology.

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RNA干扰

RNA干扰(RNAi)现象是生物进化过程中高度保守的机制。RNAi作为一种免疫系统，是植物和动物细胞中普遍存在的抵抗微生物入侵的机制。最近发现，RNAi是双链RNA(dsRNA)指导信使RNA序列特异性降解的过程，序列特异性信使RNA降解的介质是由内源性较长的dsRNA或通过转染技术从异源dsRNA中产生的21和23个核苷酸的小干扰RNA。在过去的几年中，细胞通过沉默同源基因来响应dsRNA的方式揭示了生物学中的一种新的调节模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国病理生理杂志

CiteScore

0.80

自引率

0.00%

发文量

16309

期刊介绍： Chinese Journal of Pathophysiology is the only comprehensive advanced academic journal of pathophysiology in China, which is supervised by China Association for Science and Technology, sponsored by Chinese Pathophysiology Society and hosted by Jinan University. Journal of pathophysiology research (including experimental research and clinical research), thematic reviews, experimental technology innovation and improvement, focusing on the introduction of disease pathogenesis. The current Chinese Journal of Science Pathophysiology has been included in the core Database of China Science Citation Database (CSCD), CNKI, Wanfang, Vipp, Superstar, Scopus, EBSCO, Chemical Abstracting (CA), JST, WHO Western Pacific Regional Medical Index (W PRIM) and other databases included.