What is the Prostate-Specific Antigen Cut-Off Value to Detect Clinically Significant Prostate Cancer According to Age in Turkey?

Abstract

Ad dress for Cor res pon den ce: Engin Kaya MD, University of Health Sciences, Gülhane Training and Research Hospital, Clinic of Urology, Ankara, Turkey Phone: +90 312 304 56 01 E-mail: drenginkaya@yahoo.com ORCID-ID: orcid.org/0000-0002-5112-6063 Re cei ved: 05.01.2018 Ac cep ted: 28.02.2018 Objective: To detect a prostate-specific antigen (PSA) cut-off for clinically significant prostate cancer (csPCa) according to age in Turkey. Materials and Methods: A total of 532 men who had transrectal ultrasound-guided biopsy of the prostate due to elevated PSA and abnormal findings on digital rectal examination between January 2011 and January 2018 were retrospectively evaluated. Elevated PSA was defined as ≥4 ng/mL. Patients were divided into groups 1-5 according to age: 40-49, 50-59, 60-69, 70-79, and ≥80 years. A PSA cut-off value was determined for each group. Results: The mean age was 66.45±8.21 (41-89) years. There were 20, 112, 222, 154, and 24 patients in groups 1-5, respectively. Mean PSA values were 6.04±3.88 (0.24-16.46) ng/mL, 6.8±4.17 (0.97-35.07) ng/mL, 10.51±8.53 (0.72-128.5) ng/mL, 20.41±36.64 (1.32-250) ng/mL, and 73.28±100.19 (9.33-344.1) ng/mL in groups 1-5, respectively. PSA cut-off values for csPCa were 7.08 ng/mL, 4.71 ng/mL, 7.30 ng/mL, 8.12 ng/mL, and 14.12 ng/mL in groups 1-5, respectively. Conclusion: There is a correlation between PSA and age in Turkey. Using the PSA cut-off values determined in our study would decrease the number of unnecessary biopsy procedures.