Histological Changes in the Kidney of Norwagian Rat (Rattus norvegicus) Fed with Dietary Cadmium

Discovery and Innovation Pub Date : 2009-02-13 DOI:10.4314/DAI.V19I2.15789

P. Tawari-Fufeyin, J. Oronsaye, Ah Oshoma

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Abstract

Histological changes in the kidney tissues of albino rats ( Rattus norvegicus ) fed 100mg/kg body weight of cadmium sulphate incorporated as food material has been studied in vivo in an acute toxicological experiment. The behavioural pattern and physical changes in the rats were also investigated. Loss of weight and increased locomotor activity was observed. Rats were sacrificed the kidneys dissected out and dehydrated in an ethanol series. Sections of tissues were obtained using a microtome, double stained with haematoxylin and eosin. Photographs were taken using a microscope. Histological investigations of the poisoned tissues revealed progressive increase of dark stained metabolites present in the cortex, renal papillae and medulla. The nuclei of the tubular cells showed slight reductions in size and became less prominent as the period of exposure to the poison increased. The glomeruli were observed to have very dark stained appearance, which was suggested to have come about as a result of Cadmium infiltration. There was an observed reduction in the thickness of the capsule of the kidney, which calls for closer attention Discovery and Innovation Vol. 19 (2) 2007: pp. 96-101

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饲粮镉对挪威大鼠肾脏组织的影响

采用急性毒理学实验方法，研究了100mg/kg体重硫酸镉对白化大鼠肾脏组织的影响。研究了大鼠的行为模式和生理变化。观察到体重减轻和运动活动增加。处死大鼠，取肾，乙醇脱水。使用切片机获得组织切片，用血红素和伊红双染色。照片是用显微镜拍摄的。中毒组织的组织学检查显示，皮层、肾乳头和髓质中代谢物的深色染色逐渐增加。随着中毒时间的延长，小管细胞的细胞核显示出轻微的缩小，并变得不那么突出。肾小球呈深黑色，可能是镉浸润的结果。发现与创新Vol. 19 (2) 2007: pp. 96-101有观察到的肾囊厚度减少，这需要更密切的关注

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Discovery and Innovation

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