Cancer cells remodeling and quality control are inextricably linked to autophagy

IF 0.7 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Chunzheng Li, Chenyu Wei, Gongke Zhao, Xianguang Yang
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引用次数: 0

Abstract

Autophagy is a normal cellular physiological process. As one of the cell degradation systems, it participates in the lysosomal pathway process of degrading damaged proteins and subcellular organelles to maintain cell metabolism and energy states. Moreover, autophagy is essential for regulating organelle quality control and cell homeostasis. In recent decades, a large number of studies have demonstrated that autophagy abnormalities are present in a variety of human malignancies and that autophagy plays a crucial role in all stages of tumor development. Multiple tumors interfere with autophagy's normal regulation and use autophagy's essential properties to restructure their proteome, reprogram their metabolism, and adapt to stress. This article primarily discusses how autophagy either promotes or inhibits cancer development, the significance of autophagy in maintaining cell genome stability, and the role of selective autophagy in the reshaping and quality control of tumor cells.
癌细胞的重塑和质量控制与自噬有着千丝万缕的联系
自噬是一种正常的细胞生理过程。作为细胞降解系统之一,它参与降解受损蛋白和亚细胞器的溶酶体途径过程,维持细胞代谢和能量状态。此外,自噬对细胞器质量控制和细胞稳态的调节至关重要。近几十年来,大量研究表明,自噬异常存在于多种人类恶性肿瘤中,并且自噬在肿瘤发展的各个阶段都起着至关重要的作用。多种肿瘤干扰自噬的正常调节,并利用自噬的基本特性来重组其蛋白质组,重新编程其代谢,并适应应激。本文主要讨论自噬如何促进或抑制肿瘤的发展,自噬在维持细胞基因组稳定性中的意义,以及选择性自噬在肿瘤细胞重塑和质量控制中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
AIMS Molecular Science
AIMS Molecular Science BIOCHEMISTRY & MOLECULAR BIOLOGY-
自引率
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4
审稿时长
5 weeks
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