Comparison of Interpupillary Distance, Pupillary Diameter and Corneal Reflex Measured with Plusoptix A09 in Normally Developing Children and Autism

İ. Şahbaz, Emre Taşdöndüren, Ö. Özcan, T. Erguzel, M. Karahan, M. Konuk, N. Tarhan
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Abstract

Aim: Autism Spectrum Disorder (ASD) is a developmental disorder that can present with an abnormality of the autonomic nervous system (ANS symptoms).Method: In this study, 38 eyes of 19 ASD were included with 19 healthy children (control group). Participants were analyzed according to their characteristics. Here, used the Plusoptix A09 devices to measure the difference in pupil size, corneal reflex, and interpupillary distance (IPD) between ASD and healthy children.Results: The mean age±standard deviation (SD) for the autism group was 4,6±2,5 years (range 2-11 years). In the group of normally developing children, the mean age was±SD 5,02±2,6 years (range 2-11 years). The size of the right pupil (p=0,006) and left pupil (p=0,007) was found to be significantly different in the control and experimental groups. IPD (p=0,000) was statistically significant between groups unlike the corneal reflex was not (p=0,173). The p-value is less than 0,05 in all statistical results.Conclusion: As a result, pupil diameter and IPD of children with autism were found to be larger than the control group, but there was no significant difference in corneal reflex. Pupillary measurements reveal differences between people with ASD.  
应用Plusoptix A09测量正常发育儿童与自闭症儿童瞳孔间距、瞳孔直径及角膜反射的比较
目的:自闭症谱系障碍(ASD)是一种发育障碍,可表现为自主神经系统异常(ANS症状)。方法:选取19例ASD患儿38只眼与19例健康儿童作为对照组。根据参与者的特征进行分析。本研究使用Plusoptix A09测量ASD儿童与健康儿童瞳孔大小、角膜反射和瞳孔间距(IPD)的差异。结果:自闭症组的平均年龄±标准差(SD)为4,6±2,5岁(范围2-11岁)。正常发育儿童组平均年龄±SD 5.02±2.6岁(2 ~ 11岁)。右瞳孔大小(p= 0.006)和左瞳孔大小(p= 0.007)在对照组和实验组中有显著差异。IPD组间差异有统计学意义(p= 0000),角膜反射组间差异无统计学意义(p= 0173)。所有统计结果的p值均小于0.05。结论:自闭症患儿瞳孔直径和IPD均大于对照组,但角膜反射无显著差异。瞳孔测量揭示了自闭症患者之间的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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