Inbred Mouse Strain Susceptibility to Tuberculosis Infection Vary with Phenotype, the Dose of Infection, Obesity and Composition of the Intestinal Microbiome

Abstract

In this work, we conducted comparative studies of inbred mice with different sensitivity to tuberculosis infection, I/St susceptible, C57BL/6 resistant. Two other strains C3H.JK (H2j), C3H/HeDiSn (H2k) began to grow fat by 4-5 months of age and changed their susceptibility depending on the dose of infection. Also, they were made obese or not in dependence on the dose of infection.