Aislamiento de exosomas a partir de biopsia líquida y su potencial aplicación en la clínica

IF 0.2 Q4 ONCOLOGY

Revista Colombiana de Cancerologia Pub Date : 2022-01-01 DOI:10.35509/01239015.733

Josefa Antonia Rodríguez García, Paula Daniela Morales, N. Molina

引用次数: 0

Abstract

Exosomes are extracellular micro-vesicles secreted by all cell types that have become of high-priority due to their potential clinical application for identification of new biomarkers for diagnosis, prognosis, and monitoring of neuro degenerative diseases and cancer and also, to determine their potential therapeutic application. Since these vesicles are found naturally in body fluids such as blood, urine, or saliva, it is possible to isolate them from a liquid biopsy to analyze their content, elucidate their interaction with different cell populations (crosstalk), and determine its effect during the development of particular pathologies. In this review we address the latest findings related to the design and application of extracellular vesicle-based therapies, particularly exosomes, for the treatment of cancer or as biomarkers for diagnosis, prognosis, or monitoring of diseases.

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液体活检外泌体分离及其在临床中的潜在应用

外泌体是由所有细胞类型分泌的细胞外微囊泡，由于其在诊断、预后和监测神经退行性疾病和癌症方面的潜在临床应用，以及确定其潜在的治疗应用，已成为高度优先考虑的生物标志物。由于这些囊泡自然存在于体液中，如血液、尿液或唾液中，因此可以从液体活检中分离出它们以分析其内容，阐明它们与不同细胞群的相互作用(串扰)，并确定其在特定病理发展过程中的作用。在这篇综述中，我们讨论了与基于细胞外囊泡疗法的设计和应用相关的最新发现，特别是外泌体，用于治疗癌症或作为诊断、预后或疾病监测的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Colombiana de Cancerologia ONCOLOGY-

自引率

50.00%

发文量

期刊介绍： The Revista Colombiana de Cancerología is an official publication of the Instituto Nacional de Colombia (INC). The Revista is published quarterly with the aim of broadening and disseminating knowledge in the field of oncology. The Revista publishes articles on: molecular carcinogenic mechanisms and treatment responses; cancer epidemiology; clinical features and treatment of neoplastic disease and public health campaigns to control cancer. Manuscripts which contain original material shall be accepted for possible publication. Neither the article nor any part of its contents (including statistical or graphic content) may have been published or submitted for publication in any media other than the Revista Colombiana de Cancerología. No acceptance shall be made of preliminary reports (abstracts or posters) presented at scientific meetings, neither of press releases on programmed meetings. All manuscript copies shall be placed at the disposition of the Journal Editorial Board. Under exceptional circumstances, secondary publications in Spanish or other languages may be submitted, provided they comply with certain conditions which justify said submission.