Effect of Actovegin® Versus Cortisone on PMA‐Induced Inflammation on Human Cells

Abstract

Purpose: The effect of Actovegin® versus Cortisone was investigated on PMA induced human Peripheral Blood Mononuclear Cells (PBMCs). Methods: PBMCs (1 × 10 cells/ml) from ten blood donors (5 f, 5 m; 45–55 years) were grown in medium and exposed to Actovegin® or Cortisone in the presence or absence of PMA. Supernatants were collected to assess the concentration of cytokines/substances: IL-6, TNF-α, IL-8, IL-1 beta, and IL-10. The Reactive Oxygen Species (ROS) were assessed