NANOSTRUCTURED CURCUMIN WITH CHOLINE AND GERANIC ACID IONIC LIQUID (CAGE-IL): POTENTIAL FOR INCORPORATION INTO PHARMACEUTICAL GEL FORMULATIONS

IF 0.5 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Quimica Nova Pub Date : 2023-05-08 DOI:10.21577/0100-4042.20230012

M. Vila, Rodrigo Boscariol, V. Balcão

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引用次数: 1

Abstract

Curcumin, a phytochemical, exhibits several biological properties and has been studied for the treatment of psoriasis. To facilitate its transdermal permeation, permeation enhancers such as choline and geranic acid ionic liquid (CAGE-IL) have been studied. From this perspective, the research effort entertained herein aimed at developing and evaluating the stability of an emulsion prepared with curcumin (phytochemical from Curcuma longa L.) and locust bean gum (extracted from the seeds of the carob tree, Ceratonia siliqua), with CAGE-IL as a facilitator of transdermal permeation. Stability studies were carried out for six months, with analyses being performed at time intervals of 0 (24 h), 30, 60, 90, and 180 days. The samples were kept at 40 ± 2 °C, with 75 ± 5% relative humidity (RH). The parameters analyzed were morphological characteristics, pH (5.8-6.0), and spreadability. The samples were shown to be stable during the timeframe studied, maintaining adequate physicochemical characteristics and meeting quality specifications for cutaneous applications. CAGE-IL, in addition to facilitating permeation of the active substance, also favored the formation of a stable emulsion encompassing nanosized particles (134.3 ± 2.6 nm) in a simple fashion and with only a few components.

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纳米结构姜黄素与胆碱和天竺葵酸离子液体(笼- il):合并到药物凝胶制剂的潜力

姜黄素是一种植物化学物质，具有多种生物学特性，已被研究用于治疗牛皮癣。为了促进其透皮渗透，研究了胆碱和天竺葵酸离子液体(CAGE-IL)等透皮促进剂。从这个角度来看，本文的研究工作旨在开发和评估姜黄素(姜黄中的植物化学物质)和刺槐豆胶(从角豆树Ceratonia siliqua的种子中提取)制备的乳液的稳定性，并以CAGE-IL作为透皮渗透的促进剂。稳定性研究进行了6个月，分析时间间隔为0(24小时)、30、60、90和180天。样品保存温度为40±2℃，相对湿度为75±5%。分析的参数包括形态特征、pH值(5.8-6.0)和铺展性。在研究的时间范围内，样品被证明是稳定的，保持足够的物理化学特性，并符合皮肤应用的质量规范。CAGE-IL除了促进活性物质的渗透外，还有利于以简单的方式形成稳定的乳液，其中包含纳米颗粒(134.3±2.6 nm)，并且只有少量组分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quimica Nova 化学-化学综合

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

2-4 weeks

期刊介绍： Química Nova publishes in portuguese, spanish and english, original research articles, revisions, technical notes and articles about education in chemistry. All the manuscripts submitted to QN are evaluated by, at least, two reviewers (from Brazil and abroad) of recognized expertise in the field of chemistry involved in the manuscript. The Editorial Council can be eventually asked to review manuscripts. Editors are responsible for the final edition of QN.