Control Inflammatory Effect in Tissue Engineering with Chitosan Nanoparticles, Influence of Sterilization Process

Abstract

Tissue engineering and regenerative medicine are disciplines in constant evolution to provide solutions, to assist and accelerate the regeneration and repairing of defective and damaged tissues. Many repair techniques produce inflammatory effects that difficult the regenerative process. In the present work we present a summary of our experience in using chitosan formulations as cells carrier for bone and cartilage regeneration. We have found that the use of chitosan lead to inflammatory processes in tissular repairing. To overcome this we proposed the introduction of anti-inflammatory products during the tissular regeneration and here we describe the experimental results on the control inflammatory effect in tissue engineering with chitosan nanoparticles under different sterilization process. It was found that chitosan nanoparticles have potential applications for several therapeutical drugs administration.