Cannabinoid oilwith gabapentin for the treatment of chronicneuropathic pain– case report

IF 0.4 4区农林科学 Q4 VETERINARY SCIENCES

Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice Pub Date : 2023-01-01 DOI:10.21521/mw.6755

Magdalena E. Wysmołek, Filip Pankowski, U. Latek

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引用次数: 0

Abstract

A 3-year-old Leonberger was presented with unilateral atrophy of the left temporal muscle, concomitant left corneal hypoesthesia and jaw pain. Based on magnetic resonance imaging (MRI) results, a trigeminal peripheral nerve sheath tumor was presumptively diagnosed, and treatment based on volumetric modulated arc therapy combined with temozolomide was introduced. Although the tumor volume was stable, after 6 months the patient developed severe jaw pain manifested by rubbing of the face, aversion to eating, and yawning. No desirable response to combinations of meloxicam, gabapentin, tramadol/buprenorphine at their maximal tolerated doses was achieved. Only a treatment based on a commercially available nonpsychoactive cannabinoid oil – Perognidol® (Ilovet) combined with gabapentin successfully relieved the symptoms of pain within a week. Three months later, a follow-up MRI revealed a significant growth of the tumor associated with cerebral infiltration. Eventually, the general condition of the patient deteriorated. The dog was euthanized 800 days after the original diagnosis.

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大麻素油联合加巴喷丁治疗慢性神经性疼痛1例

一个3岁的Leonberger被提出单侧左侧颞肌萎缩，伴随左侧角膜感觉减退和下颚疼痛。根据磁共振成像(MRI)结果，推测诊断为三叉周围神经鞘肿瘤，并介绍了基于体积调制弧疗法联合替莫唑胺的治疗。虽然肿瘤体积稳定，但6个月后患者出现严重的下颌疼痛，表现为摩擦面部，厌恶进食，打哈欠。美洛昔康、加巴喷丁、曲马多/丁丙诺啡在其最大耐受剂量下联合使用没有理想的反应。只有基于市售的非精神活性大麻素油- Perognidol®(Ilovet)联合加巴喷丁的治疗才能在一周内成功缓解疼痛症状。三个月后，随访MRI显示肿瘤明显生长并伴有大脑浸润。最后，病人的一般情况恶化了。这只狗在最初的诊断后800天被安乐死。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice VETERINARY SCIENCES-

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： "Medycyna Weterynaryjna" publishes various types of articles which are grouped in the following editorial categories: reviews, original studies, scientific and professional problems, the history of veterinary medicine, posthumous memoirs, as well as chronicles that briefly relate scientific advances and developments in the veterinary profession and medicine. The most important are the first two categories, which are published with short summaries in English. Moreover, from 2001 the editors of "Medycyna Weterynaryjna", bearing in mind market demands, has also started publishing entire works in English. Since 2008 the periodical has appeared in an electronic version. The following are available in this version: summaries of studies published from 1999 to 2005, full versions of all the studies published in the years 2006-2011 (in pdf files), and full versions of the English studies published in the current year (pdf). Only summaries of the remaining studies from the current year are available. In accordance with the principles accepted by the editors, the full versions of these texts will not be made available until next year. All articles are evaluated twice by leading Polish scientists and professionals before they are considered for publication. For years now "Medycyna Weterynaryjna" has maintained a high standard thanks to this system. The review articles are actually succinct monographs dealing with specific scientific and professional problems that are based on the most recent findings. Original works have a particular value, since they present research carried out in Polish and international scientific centers.