Affinity-Division Multiplexing for Molecular Communications With Promiscuous Ligand Receptors

IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Transactions on Molecular, Biological, and Multi-Scale Communications Pub Date : 2023-07-13 DOI:10.1109/TMBMC.2023.3295338

Ahmet R. Emirdagi;M. Serkan Kopuzlu;M. Okan Araz;Murat Kuscu

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引用次数: 0

Abstract

A key challenge in Molecular Communications (MC) is low data transmission rates, which can be addressed by channel multiplexing techniques. One way to achieve channel multiplexing in MC is to leverage the diversity of different molecule types with respect to their receptor binding characteristics, such as affinity and kinetic binding/unbinding rates. In this study, we propose a practical multiplexing scheme for MC, which is based on the diversity of ligand-receptor binding affinities. This method requires only a single type of promiscuous receptor on the receiver side, capable of interacting with multiple ligand types. We analytically derive the mean Bit Error Probability (BEP) over all multiplexed MC channels as a function of similarity among ligands in terms of their receptor affinities, the number of receptors, the number of multiplexed channels, and the ratio of concentrations encoding bit-1 and bit-0. We investigate the impact of each design parameter on the performance of multiplexed MC system.

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与混杂配体受体进行分子通讯的亲和分裂复用

分子通信（MC）的一个关键挑战是低数据传输速率，这可以通过信道复用技术来解决。在MC中实现通道复用的一种方法是利用不同分子类型在受体结合特性方面的多样性，如亲和力和动力学结合/解结合率。在这项研究中，我们提出了一种实用的MC多路复用方案，该方案基于配体-受体结合亲和力的多样性。这种方法只需要受体侧的单一类型的混杂受体，能够与多种配体类型相互作用。我们分析推导了所有多路复用MC通道的平均误比特概率（BEP），作为配体之间相似性的函数，包括它们的受体亲和力、受体数量、多路复用通道数量以及编码比特-1和比特-0的浓度比。研究了各设计参数对多路复用MC系统性能的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Transactions on Molecular, Biological, and Multi-Scale Communications Mathematics-Modeling and Simulation

CiteScore

3.90

自引率

13.60%

发文量

期刊介绍： As a result of recent advances in MEMS/NEMS and systems biology, as well as the emergence of synthetic bacteria and lab/process-on-a-chip techniques, it is now possible to design chemical “circuits”, custom organisms, micro/nanoscale swarms of devices, and a host of other new systems. This success opens up a new frontier for interdisciplinary communications techniques using chemistry, biology, and other principles that have not been considered in the communications literature. The IEEE Transactions on Molecular, Biological, and Multi-Scale Communications (T-MBMSC) is devoted to the principles, design, and analysis of communication systems that use physics beyond classical electromagnetism. This includes molecular, quantum, and other physical, chemical and biological techniques; as well as new communication techniques at small scales or across multiple scales (e.g., nano to micro to macro; note that strictly nanoscale systems, 1-100 nm, are outside the scope of this journal). Original research articles on one or more of the following topics are within scope: mathematical modeling, information/communication and network theoretic analysis, standardization and industrial applications, and analytical or experimental studies on communication processes or networks in biology. Contributions on related topics may also be considered for publication. Contributions from researchers outside the IEEE’s typical audience are encouraged.