Experience of rehabilitation of children with lung damage associated with COVID-19 in the post-covid period

Q3 Medicine
T. A. Gutyrchik, A. B. Malakhov, A. Sedova, P. Berezhanskiy, N. Kolosova, T. Yushina
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Abstract

The variety of clinical symptoms in the post-COVID period and the long period of their persistence determine the relevance of timely and adequate rehabilitation of patients. Patients and methods. The observational study involved 40 children aged 7 to 18 years at the stage of rehabilitation after COVID-19 with lung damage. Two groups of patients were identified: the control group (n = 20) received standard therapy (inhaled glucocorticosteroids (IGCs), vitamins, anticoagulants); the study group (n = 20) received ammonium glycyrrhizinate (AG) in addition to standard therapy for 30 days. The groups underwent a physical examination, measurement of spirometry, scoring of general and respiratory symptoms and adverse events on days 1, 14, and 30 of therapy. Results. By day 30 of AG therapy, the frequency of cough decreased by 30% in the study group, and the symptom of weakness was eliminated in 50% of children; in the control group, cough persisted in all patients (p = 0.01), weakness was recorded in 90% of patients (p = 0.005). In the study group compared to the control, there was a significantly faster regression of symptom severity. By the 30th day of observation, VAS cough scores in the study group were 0.75 ± 0.4 points, which was 2.5 times lower than in the control group (1.85 ± 0.3 points, p = 0.002); weakness scores in patients in the study group were 2.8 times lower than in the control (0.45 ± 0.4 and 1.25 ± 0.3 points, respectively, p = 0.005). In all patients in the study group, the normalization of spirometry was recorded by day 30, while the majority of control group patients had no such positive dynamics. Conclusion. The inclusion of AG in a course of 30 days in the complex rehabilitation of patients after COVID-19 with lung damage provides a rapid regression of the severity of respiratory and general symptoms of the post-COVID period, which can significantly improve the quality of life of patients and the prognosis of the disease. Key words: coronavirus infection, COVID-19, post-COVID syndrome, children, rehabilitation, ammonium glycyrrhizinate, glycyrrhizic acid
新冠肺炎相关肺损伤患儿术后康复体会
新冠肺炎后临床症状的多样性和持续时间的长期性决定了患者及时充分康复的重要性。患者和方法。这项观察性研究涉及40名年龄在7至18岁的儿童,他们在COVID-19后的康复阶段患有肺损伤。将患者分为两组:对照组(n = 20)接受标准治疗(吸入糖皮质激素(IGCs)、维生素、抗凝剂);研究组(n = 20)在标准治疗的基础上给予甘草酸铵(AG)治疗,疗程30天。各组在治疗的第1、14和30天进行体格检查,测量肺活量,对一般症状和呼吸系统症状及不良事件进行评分。结果。AG治疗第30天,研究组咳嗽次数减少30%,50%患儿无力症状消失;对照组患者持续咳嗽(p = 0.01), 90%的患者出现虚弱(p = 0.005)。与对照组相比,研究组症状严重程度的消退明显更快。观察第30天,研究组VAS咳嗽评分为0.75±0.4分,比对照组(1.85±0.3分,p = 0.002)低2.5倍;研究组患者的无力评分比对照组低2.8倍(分别为0.45±0.4分和1.25±0.3分,p = 0.005)。研究组所有患者均在第30天记录肺活量正常化,而对照组大部分患者无此阳性动态。结论。在新冠肺炎合并肺损伤患者的复杂康复治疗中,将AG纳入30天的疗程,可使患者术后呼吸系统和一般症状的严重程度迅速消退,可显著改善患者的生活质量和疾病预后。关键词:冠状病毒感染,COVID-19,后冠综合征,儿童,康复,甘草酸铵,甘草酸
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来源期刊
Voprosy Prakticheskoi Pediatrii
Voprosy Prakticheskoi Pediatrii Medicine-Pediatrics, Perinatology and Child Health
CiteScore
1.20
自引率
0.00%
发文量
50
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