HUBUNGAN ANTARA AKTIVASI MAKROFAG DENGAN KADAR INTERLEUKIN-6 DAN ANTIBODI TERHADAP Salmonella typhi PADA MENCIT (Relationship between the Macrophage Activity with Interleukin-6 Levels and Titers of Antibodies against Salmonella typhi)

Jurnal Kedokteran Hewan Pub Date : 2016-03-15 DOI:10.21157/J.KED.HEWAN.V10I1.3359

I. Besung, N. Astawa, K. Suata, N. K. Suwiti

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引用次数: 6

Abstract

This study aims to determine the relationships between macrophage activities and interleukin-6 (IL-6 levels), and titer antibody to Salmonella typhi (S. typhi). A total of 32 mice were infected intraperitoneally with 10 5 cells/ml of S. typhi. The activities of macrophages were observed a day after the infection, while the observations of the levels of IL-6 and titer antibody employing enzyme-linked immunosorbent assay (ELISA) method were conducted after one and two weeks of infection. The results showed that the average activities of macrophages after infected by S. typhi was 77.84±11.23 sel, and the levels of IL-6 and antibody titers were higher (159.55±90.11 pg and 56.87±23.32 IU respectively). The macrophage activities were significantly increased (P<0.01) with increasing the level of IL-6 to Y= -0.317x 2 + 0.0033x 2 +494.09 with the relatedness (r)= 0.89 and the antibody titers to Y= -0.020x 2 + 0.00031x + 29.083 with the relatedness (r)= 0.95 . Key words: macrophage activity, IL-6, antibody titers, Salmonella typhi

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HUBUNGAN ANTARA AKTIVASI MAKROFAG DENGAN KADAR白细胞介素-6和抗体TERHADAP伤寒沙门氏菌PADA MENCIT

本研究旨在探讨巨噬细胞活性与白细胞介素-6 (IL-6)水平、伤寒沙门菌(S. typhi)滴度抗体之间的关系。32只小鼠腹腔感染斑疹伤寒沙门氏菌10.5个细胞/ml。感染1天后观察巨噬细胞活性，感染1周和2周后用酶联免疫吸附法(ELISA)观察IL-6和滴度抗体水平。结果表明，感染斑疹伤寒沙门氏菌后，巨噬细胞的平均活性为77.84±11.23 sel, IL-6水平和抗体滴度分别为159.55±90.11 pg和56.87±23.32 IU。巨噬细胞活性随着IL-6水平升高而显著升高(P<0.01)， Y= -0.317 × 2 + 0.0033 × 2 +494.09，相关性(r)= 0.89;抗体滴度与Y= -0.020 × 2 + 0.00031 × + 29.083，相关性(r)= 0.95。关键词:巨噬细胞活性，IL-6，抗体滴度，伤寒沙门菌

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Jurnal Kedokteran Hewan

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24 weeks