Is Gastrointestinal Metastasis of Primary Lung Malignancy as Rare as Reported in the Literature? A Comparison Between Clinical Cases and Post-mortem Studies

IF 0.7 1区历史学 Q1 HISTORY

Oral History Review Pub Date : 2016-01-01 DOI:10.17925/OHR.2016.12.01.51

Vasa Jevremovic

引用次数: 12

Abstract

TOUCH MEDICAL MEDIA 51 Malignancies of the lung are common, and are the leading cause of cancer deaths worldwide. Non-small cell lung carcinoma constitutes the majority of these lesions, with small cell lung carcinomas comprising the remainder (15%). Non-small cell lung cancers are subdivided into three histological subtypes: adenocarcinoma, large-cell carcinoma, and squamous-cell carcinoma. The subtypes are associated with various mutations, and thus demonstrate different metastatic potential. Furthermore, the heterogeneous nature of these mutations in the primary tumor produces a population of cells that have undergone the steps necessary in the metastatic cascade, leading to disease progression.

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原发性肺恶性肿瘤胃肠道转移是否像文献报道的那样罕见?临床病例与尸检研究的比较

肺恶性肿瘤很常见，是世界范围内癌症死亡的主要原因。非小细胞肺癌占这些病变的大多数，小细胞肺癌占剩余的15%。非小细胞肺癌可分为三种组织学亚型:腺癌、大细胞癌和鳞状细胞癌。这些亚型与各种突变相关，因此表现出不同的转移潜力。此外，原发肿瘤中这些突变的异质性产生了一群细胞，这些细胞在转移级联中经历了必要的步骤，导致疾病进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral History Review Multiple-

CiteScore

1.20

自引率

27.30%

发文量

期刊介绍： The Oral History Review, published by the Oral History Association, is the U.S. journal of record for the theory and practice of oral history and related fields. The journal’s primary mission is to explore the nature and significance of oral history and advance understanding of the field among scholars, educators, practitioners, and the general public. The Review publishes narrative and analytical articles and reviews, in print and multimedia formats, that present and use oral history in unique and significant ways and that contribute to the understanding of the nature of oral history and memory. It seeks previously unpublished works that demonstrate high-quality research and that offer new insight into oral history practice, methodology, theory, and pedagogy. Work published in the journal arises from many fields and disciplines, reflecting the interdisciplinary nature of oral history. While based in the U.S., the Review reflects the international scope of the field and encourages work from international authors and about international topics.