Frontispiece: A Cyclometalated IrIII Complex as a Lysosome-Targeted Photodynamic Therapeutic Agent for Integrated Imaging and Therapy in Cancer Cells

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2018-08-01 DOI:10.1002/chem.201884365

Karivachery V. Sudheesh, Prasad S. Jayaram, Dr. Animesh Samanta, Dr. Kochan S. Bejoymohandas, Dr. Ramapurath S. Jayasree, Prof.?Dr. Ayyappanpillai Ajayaghosh

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Abstract

Organelle-targeted photosensitizers with luminescence properties are potential theranostic agents for simultaneous imaging and photodynamic therapy. Described herein is a cyclometalated Ir^III complex, Ir-Bp-Ly, that exhibits high triplet quantum yield and singlet-oxygen-generation efficiency. The close-proximity energy levels between triplet energy states of Ir-Bp-Ly and molecular oxygen favors efficient singlet oxygen and reactive oxygen species (ROS) generation. The good lysosomal specificity of Ir-Bp-Ly leads to its increased efficacy as a photodynamic therapeutic and imaging agent. More information can be found in the Full Paper by A. Ajayaghosh et al. on page 10999 ff.

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前言:环金属化IrIII配合物作为溶酶体靶向的光动力治疗剂用于肿瘤细胞的综合成像和治疗

具有发光特性的细胞器靶向光敏剂是同时成像和光动力治疗的潜在治疗剂。本文描述的是一种环金属化的IrIII配合物，Ir-Bp-Ly，具有高三态量子产率和单线态产氧效率。Ir-Bp-Ly和分子氧的三重态能级接近，有利于单线态氧和活性氧(ROS)的高效生成。Ir-Bp-Ly良好的溶酶体特异性导致其作为光动力治疗和显像剂的疗效增加。更多信息可以在A. Ajayaghosh等人的论文全文中找到。在10999页。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.

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