OIL OR FLAXSEED FLOUR REDUCES PANCREATIC ISLET AREA BUT DOES NOT AFFECT SERUM INSULIN, AT WEANING, IN MALE WISTAR RATS

JAR life Pub Date : 2018-01-01 DOI:10.14283/jarcp.2018.4

A. D'Avila Pereira, D. Cavalcante Ribeiro, A. de Sousa dos Santos, B. Ferolla da Camara Boueri, C. Ribeiro Pessanha, M. Duque Coutinho de Abreu, L. Pessoa Rozeno, C. Cristina Alves do Nascimento-Saba, L. Guillermo Coca Velarde, C. A. Soares da Costa, G. Teles Boaventura

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Abstract

The aim of the present study evaluated the influence of oil or flaxseed flour in pancreas morphology of pups, whose mothers were fed with oil or flaxseed flour during lactation, at weaning. After birth, the lactating rat males were randomly assigned: control (C, n=12 pups), flaxseed oil (FO, n=12 pups) and flaxseed flour (FF, n=12). At 21 days, the pups were weaning and anesthetized. Body mass, length, serum glucose, insulin, pancreas mass and pancreatic islet area were assessed. FO and FF showed higher (p<0.05) mass and length and lower glucose (p<0.05) when compared with C. Insulin (p=0.094) and pancreas mass (p=0.054) not differ between groups. FO and FF showed lower (p<0.05) pancreatic islet area when compared with C. A fed with FO or FF, during lactation may improve function pancreatic, as insulin sensitivity. These findings emphasize that oil or flaxseed flour during lactation may improve pancreatic function in early life.

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在雄性wistar大鼠断奶时，油或亚麻籽粉可减少胰岛面积，但不影响血清胰岛素

本研究的目的是评估油或亚麻籽粉对断奶幼崽胰腺形态的影响，幼崽的母亲在哺乳期喂食油或亚麻籽粉。产后，将泌乳雄性大鼠随机分为对照组(C, n=12只)、亚麻籽油组(FO, n=12只)和亚麻籽粉组(FF, n=12只)。第21天，幼犬断奶并麻醉。评估体重、体长、血清葡萄糖、胰岛素、胰腺质量和胰岛面积。与c相比，FO和FF的质量和长度均显著增加(p<0.05)，葡萄糖含量显著降低(p<0.05)。胰岛素(p=0.094)和胰腺质量(p=0.054)各组间差异无统计学意义。与c相比，鱼油和FF的胰岛面积显著降低(p<0.05)。A在哺乳期饲喂鱼油或FF可改善胰腺功能，如胰岛素敏感性。这些发现强调，哺乳期间的油或亚麻籽面粉可能会改善生命早期的胰腺功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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JAR life

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