Effect of high background natural radioactivity on human mitochondrial DNA in Ramsar, the north of Iran

Q4 Medicine
Reza Vazifehmand, S. Saber, Abbas Takavr, Dhuha Ali, Tina Saber, Farnaz Takavar
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引用次数: 0

Abstract

Radioactivity is known to induce tumours, chromosome lesions, and mini-satellite length mutations, but also effects on the DNA sequence. Ramsar region, in the north of Iran with the highest background of natural radiation (226Ra) in the world, with a densely populated area, offers an opportunity to characterise radiation-associated DNA mutations. We sampled 30 individuals from this area and 15 cases from Tehran as controls. We sequenced their mtDNA and found multiple variations in multiple nucleotide positions in Ramsar inhabitants. 16519 and T > C were the most frequent NPS and variables in our study. In this preliminary investigation, we conclude that an elevated level of natural background radiation in Ramsar region had a significant effect on the control region of mtDNA. We think this is the first report from Ramsar in this field. Moreover, using molecular and biological pathways and study of gene expression to understand the cellular and molecular response of human mtDNA to low-dose radiation exposure is recommended.
伊朗北部拉姆萨尔地区高本底天然放射性对人类线粒体DNA的影响
已知放射性会诱发肿瘤、染色体损伤和小卫星长度突变,但也会影响DNA序列。拉姆萨尔地区位于伊朗北部,拥有世界上最高的自然辐射背景(226Ra),人口稠密,为描述与辐射相关的DNA突变提供了机会。我们从该地区抽取了30例样本,并从德黑兰抽取了15例作为对照。我们对他们的mtDNA进行了测序,发现拉姆萨尔居民的多个核苷酸位置存在多种变异。16519和t> C是我们研究中最常见的NPS和变量。在本初步调查中,我们得出结论,拉姆萨尔地区自然本底辐射水平的升高对mtDNA控制区有显著影响。我们认为这是拉姆萨尔在该领域的第一份报告。此外,建议使用分子和生物学途径以及基因表达研究来了解人类mtDNA对低剂量辐射的细胞和分子反应。
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来源期刊
International Journal of Low Radiation
International Journal of Low Radiation Environmental Science-Health, Toxicology and Mutagenesis
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期刊介绍: The IJLR is a peer-reviewed journal dedicated to the publication of research articles, review papers and technical notes in all domains related to low-dose radiation, among which are the biological and health effects in humans and the biota, in vitro and in vivo research on low radiation effects, regulatory and policy aspects, risk estimation and public perception.
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