Reza Vazifehmand, S. Saber, Abbas Takavr, Dhuha Ali, Tina Saber, Farnaz Takavar
{"title":"Effect of high background natural radioactivity on human mitochondrial DNA in Ramsar, the north of Iran","authors":"Reza Vazifehmand, S. Saber, Abbas Takavr, Dhuha Ali, Tina Saber, Farnaz Takavar","doi":"10.1504/IJLR.2015.074405","DOIUrl":null,"url":null,"abstract":"Radioactivity is known to induce tumours, chromosome lesions, and mini-satellite length mutations, but also effects on the DNA sequence. Ramsar region, in the north of Iran with the highest background of natural radiation (226Ra) in the world, with a densely populated area, offers an opportunity to characterise radiation-associated DNA mutations. We sampled 30 individuals from this area and 15 cases from Tehran as controls. We sequenced their mtDNA and found multiple variations in multiple nucleotide positions in Ramsar inhabitants. 16519 and T > C were the most frequent NPS and variables in our study. In this preliminary investigation, we conclude that an elevated level of natural background radiation in Ramsar region had a significant effect on the control region of mtDNA. We think this is the first report from Ramsar in this field. Moreover, using molecular and biological pathways and study of gene expression to understand the cellular and molecular response of human mtDNA to low-dose radiation exposure is recommended.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2015.074405","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Low Radiation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1504/IJLR.2015.074405","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Radioactivity is known to induce tumours, chromosome lesions, and mini-satellite length mutations, but also effects on the DNA sequence. Ramsar region, in the north of Iran with the highest background of natural radiation (226Ra) in the world, with a densely populated area, offers an opportunity to characterise radiation-associated DNA mutations. We sampled 30 individuals from this area and 15 cases from Tehran as controls. We sequenced their mtDNA and found multiple variations in multiple nucleotide positions in Ramsar inhabitants. 16519 and T > C were the most frequent NPS and variables in our study. In this preliminary investigation, we conclude that an elevated level of natural background radiation in Ramsar region had a significant effect on the control region of mtDNA. We think this is the first report from Ramsar in this field. Moreover, using molecular and biological pathways and study of gene expression to understand the cellular and molecular response of human mtDNA to low-dose radiation exposure is recommended.
期刊介绍:
The IJLR is a peer-reviewed journal dedicated to the publication of research articles, review papers and technical notes in all domains related to low-dose radiation, among which are the biological and health effects in humans and the biota, in vitro and in vivo research on low radiation effects, regulatory and policy aspects, risk estimation and public perception.