Study of in-vivo breast cancer in a subcutaneous xenograft mouse model using terahertz imaging

IF 0.6 4区物理与天体物理 Q4 OPTICS

红外与毫米波学报 Pub Date : 2020-01-01 DOI:10.11972/J.ISSN.1001-9014.2020.05.004

Wu Li-min, L. Bin, Xu De-gang, Wang Yu-Ye, Ge Mei-Lan, Zhang Chao-nan, Liu Jia-hua, Sun Zhong-Cheng, Chen Tu-Nan, F. Hua, Yao Jian-quan

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引用次数: 1

Abstract

Breast cancer(BC)is one of the most common diseases in women. The accurate detection for BC is very important in clinical practice. In this paper,in-vivo breast cancer in a subcutaneous xe‐ nograft mouse was studied with the continuous-wave terahertz(THz) reflection imaging system at 2. 52THz. The high reflection region in THz images of in-vivo subcutaneous xenograft mouse corre‐ sponded well to the tumor area in visible. The difference value of 15% between tumor and normal tis‐ sues was observed. For the gold standard,the tumor areas at different depths from the surface of skin 文章编号:1001-9014(2020)05-0553-08 DOI:10. 11972/j. issn. 1001-9014. 2020. 05. 004 收稿日期:2019⁃ 09⁃ 26,修回日期:2020⁃ 06⁃ 04 Received date:2019⁃ 09⁃ 26,Revised date:2020⁃ 06⁃ 04 基金项目:国家 973计划(2015CB755403),国家自然科学基金(61775160,61771332),中国博士后科学基金特别资助(2016M602954),重庆市博士后科研项目特别资助(Xm2016021),重庆西南医院生物强院科技创新计划(SWH2016LHJC04,SWH2016LHJC01) Foundation items:Supported by National Basic Research Program of China(973)(2015CB755403),National Natural Science Foundation of China (NSFC)(61775160,61771332),China Postdoctoral Science Foundation(2016M602954),Postdoctoral Science Foundation of Chongqing (Xm2016021),Joint Incubation Project of Southwest Hospital(SWH2016LHJC-04,SWH2016LHJC-01); 作者简介(Biography):武丽敏(1989-),女,山东聊城人,博士生,主要研究领域为太赫兹生物医学成像 . E-mail:wulimin@tju. edu. cn. *通讯作者(Corresponding author):E-mail:yuyewang@tju. edu. cn

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使用太赫兹成像在皮下异种移植小鼠模型中研究体内乳腺癌

乳腺癌(BC)是女性最常见的疾病之一。BC的准确检测在临床实践中非常重要。在本文中，我们用连续波太赫兹(THz)反射成像系统在2。52太赫兹。活体异种皮下移植小鼠太赫兹图像的高反射区与可见的肿瘤区域对应良好。观察到肿瘤与正常之间的差异值为15%。对于金标准，肿瘤区域距离皮肤表面不同深度[中文]:1001-9014(2020)05-0553-08 DOI:10。11972 / j。石头。1001 - 9014。2020. 05. 004收稿日期:2019⁃09年⁃26日修回日期:2020年⁃06⁃04收到日期:2019⁃09年⁃26日修订日期:2020⁃06⁃04基金项目:国家973年计划(2015 cb755403),国家自然科学基金(61775160,61775160),中国博士后科学基金特别资助(2016 m602954),重庆市博士后科研项目特别资助(Xm2016021),重庆西南医院生物强院科技创新计划(SWH2016LHJC04 SWH2016LHJC01)基金会项目:支持中国国家基础研究计划(973)(2015 cb755403),中国国家自然科学基金(国家自然科学基金委)(61775160,61771332),中国博士后科学基金会(2016 m602954),博士后科学基金重庆(Xm2016021)，西南医院联合培育项目(SWH2016LHJC-04,SWH2016LHJC-01);作者简介(传记):武丽敏(1989 -),女,山东聊城人,博士生,主要研究领域为太赫兹生物医学成像。电子邮件:wulimin@tju。edu。cn。*通讯作者:E-mail:yuyewang@tju。edu。cn

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