Effects of prototype low viscid toothpaste containing cetylpyridinium chloride with interproximal brushes on gingivitis

Q4 Pharmacology, Toxicology and Pharmaceutics
T. Nomura, Takashi Yanagisawa, M. Yuasa, K. Kamo, Yoshio Saito, Noriaki Yoshida, T. Arai
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引用次数: 0

Abstract

There have been many applications of toothpastes and gargles containing antibiotic ingredients to periodontal treatment. Cetylpyridinium chloride (CPC) is one such anti-plaque ingredient with a content of 0.05%. This study evaluated the effects of interproximal brushes with a prototype low viscid toothpaste containing 0.05% of CPC on slight periodontitis and gingivitis at interproximal areas. The subjects were 60 patients who had not received general and/or local antibiotics or periodontal therapy for at least 3 months prior to this study. They had at least 1 interproximal area where interproximal brushes could be inserted on the maxillar or mandibular incisors to second premolars without prosthesis. Sampling sites were interproximal areas in each subject. The subjects in the experimental group were instructed as to brushing method and used interproximal brushes with the prototype low viscid toothpaste containing 0.05% of CPC. The other subjects in the placebo group used a prototype low viscid toothpaste without CPC and were given the same instructions as the experimental group of subjects. Mondified gingival index (MGI), modified plaque index (MPI) , amount of gingival cervical fluid (GCF) , probing depth (PD), clinical attachment level (CAL) and ratio of subgingival microflora were measured at baseline, and after 1 month and 2 months. The data from 23 patients in the experimental group and 25 patients in the placebo group were adopted in this study. MGI, MPI, GCF and PD in both groups showed a significant reduction with time. GCF and PD in the experimental group were significantly lower than those of the placebo group at 1 month. CAL in both groups did not change at any period. Ratio of cocci increased with time in both groups, accordingly rods decreased with time. Spirochetes and motile rods were scarcely detected at every period. These results suggested that the use of low viscid toothpaste containing 0.05% of cetypyridinium chloride with interproximal brushes could quickly improve gingivitis.
含十六烷基吡啶氯化钠低粘度牙膏原型与近端刷对牙龈炎的影响
含有抗生素成分的牙膏和漱口水在牙周治疗中有很多应用。十六烷基氯化吡啶(CPC)就是其中一种抗菌斑成分,含量为0.05%。本研究评估了含0.05% CPC的低粘性牙膏原型近端间刷对近端间轻度牙周炎和牙龈炎的影响。研究对象为60例患者,在本研究前至少3个月未接受普通和/或局部抗生素或牙周治疗。他们至少有一个近端间区,近端间刷可以插入上颌或下颌门牙至第二前磨牙,无需假体。采样地点为每个受试者的近端间区。实验组在指导刷牙方法的基础上,使用含0.05% CPC的低粘牙膏原型近端间刷。安慰剂组的其他受试者使用不含CPC的低粘度牙膏原型,并给予与实验组受试者相同的说明。在基线、1个月和2个月后分别测量改良龈指数(MGI)、改良菌斑指数(MPI)、龈宫颈液量(GCF)、探诊深度(PD)、临床附着水平(CAL)和龈下菌群比例。本研究采用实验组23例患者和安慰剂组25例患者的数据。两组患者的MGI、MPI、GCF和PD均随时间的延长而显著降低。1个月时,实验组GCF和PD显著低于安慰剂组。两组的CAL在任何时期都没有变化。两组的球菌比例随时间增加而增加,杆状体随时间减少。螺旋体和活动杆几乎在每个时期都检测不到。结果提示,使用含0.05%氯化头孢啶的低粘度牙膏配合近端刷可以快速改善牙龈炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Oral Therapeutics and Pharmacology
Oral Therapeutics and Pharmacology Medicine-Pharmacology (medical)
CiteScore
0.10
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