Effect of 2,3 Butanedione Monoxime (BDM) on ventricular fibrillation

M. Malik, M. Gopalakrishnan, R. Malkin
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引用次数: 1

Abstract

Optical mapping is commonly used to study ventricular fibrillation (VF). Electro-contractile uncouplers like 2,3 Butanedione Monaxime (BDM) are used in these studies to stop the mechanical activity wider the assumption that they do not have an effect on the electrical activity. Our objective is to test this assumption. Male guinea pigs were used in this study. The Animals were anaesthetized and median sternotomy and pericardiectomy were performed to expose the heart An Intracardiac injection of BDM was administered and VF was induced Epicardial unipolar recordings were made for 4s using an electrode array along with a video recording of the heart The procedure was repeated for saline and control. Quantitative analysis of the data was performed using autocorrelation analysis. BDM significantly decreases the mechanical activity of the heart and increased the level of temporal organization during VF.
2,3丁二酮单肟(BDM)对心室颤动的影响
光学成像是研究心室颤动(VF)的常用方法。像2,3丁二酮单胺(BDM)这样的电收缩解耦剂在这些研究中被用来阻止机械活动,更广泛地假设它们对电活动没有影响。我们的目标是验证这个假设。本研究使用雄性豚鼠。麻醉动物,切开胸骨正中切口和心包切开术暴露心脏,在心内注射BDM并诱导VF,使用电极阵列记录心外膜单极记录45秒,并记录心脏的视频,盐水和对照组重复该过程。采用自相关分析对数据进行定量分析。BDM显著降低心脏的机械活动,增加VF期间的颞叶组织水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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