The role of endothelial cells on islet function and revascularization after islet transplantation

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Organogenesis Pub Date : 2016-01-02 DOI:10.1080/15476278.2016.1165378

A. del Toro-Arreola, A. K. Robles-Murillo, A. Daneri-Navarro, J. Rivas-Carrillo

引用次数: 22

Abstract

ABSTRACT Islet transplantation has become a widely accepted therapeutic option for selected patients with type 1 diabetes mellitus. However, in order to achieve insulin independence a great number of islets are often pooled from 2 to 4 pancreata donors. Mostly, it is due to the massive loss of islets immediately after transplant. The endothelium plays a key role in the function of native islets and during the revascularization process after islet transplantation. However, if a delayed revascularization occurs, even the remaining islets will also undergo to cell death and late graft dysfunction. Therefore, it is essential to understand how the signals are released from endothelial cells, which might regulate both differentiation of pancreatic progenitors and thereby maintenance of the graft function. New strategies to facilitate islet engraftment and a prompt revascularization could be designed to intervene and might lead to improve future results of islet transplantation.

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内皮细胞在胰岛移植后胰岛功能和血运重建中的作用

胰岛移植已成为1型糖尿病患者广泛接受的治疗选择。然而，为了实现胰岛素独立性，大量的胰岛通常由2到4个胰腺供体汇集。大多数情况下，这是由于移植后立即大量失去胰岛。内皮在天然胰岛的功能和胰岛移植后的血运重建过程中起着关键作用。然而，如果发生延迟的血运重建，即使是剩余的胰岛也会发生细胞死亡和晚期移植物功能障碍。因此，了解内皮细胞如何释放信号至关重要，这可能调节胰腺祖细胞的分化，从而维持移植物功能。促进胰岛移植和及时血运重建的新策略可以被设计用于干预，并可能导致改善未来胰岛移植的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.