The role of long non-coding RNAs and circular RNAs in bone regeneration: Modulating miRNAs function

IF 3.1 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2021-12-27 DOI:10.1002/term.3277

Jianfeng Ping, Laifeng Li, Yongqiang Dong, Xudong Wu, Xiaogang Huang, Bin Sun, Bin Zeng, Fangming Xu, Wenqing Liang

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引用次数: 7

Abstract

Although bone is a self-healing organ and is able to repair and restore most fractures, large bone fractures, about 10%, are not repairable. Bone grafting, as a gold standard, and bone tissue engineering using biomaterials, growth factors, and stem cells have been developed to restore large bone defects. Since bone regeneration is a complex and multiple-step process and the majority of the human genome, about 98%, is composed of the non-protein-coding regions, non-coding RNAs (ncRNAs) play essential roles in bone regeneration. Recent studies demonstrated that long ncRNAs (lncRNAs) and circular RNAs (circRNAs), as members of ncRNAs, are widely involved in bone regeneration by interaction with microRNAs (miRNAs) and constructing a lncRNA or circRNA/miRNA/mRNA regulatory network. The constructed network regulates the differentiation of stem cells into osteoblasts and their commitment to osteogenesis. This review will present the structure and biogenesis of lncRNAs and circRNAs, the mechanism of bone repair, and the bone tissue engineering in bone defects. Finally, we will discuss the role of lncRNAs and circRNAs in osteogenesis and bone fracture healing through constructing various lncRNA or circRNA/miRNA/mRNA networks and the involved pathways.

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长链非编码rna和环状rna在骨再生中的作用:调节miRNAs的功能

虽然骨是一种自我修复的器官，能够修复和恢复大多数骨折，但大约10%的大骨折是不可修复的。骨移植作为金标准，以及使用生物材料、生长因子和干细胞的骨组织工程已经发展到修复大型骨缺损。由于骨再生是一个复杂的多步骤过程，并且人类基因组的大部分(约98%)由非蛋白编码区组成，因此非编码rna (ncRNAs)在骨再生中起着至关重要的作用。最近的研究表明，长ncRNAs (lncRNAs)和环状rna (circRNAs)作为ncRNAs的成员，通过与microRNAs (miRNAs)相互作用，构建lncRNA或circRNA/miRNA/mRNA调控网络，广泛参与骨再生。构建的网络调节干细胞向成骨细胞的分化及其对成骨的承诺。本文将对lncrna和circrna的结构和生物发生、骨修复机制以及骨组织工程在骨缺损中的应用进行综述。最后，我们将通过构建各种lncRNA或circRNA/miRNA/mRNA网络及其相关通路，讨论lncRNA和circRNA在成骨和骨折愈合中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Tissue Engineering and Regenerative Medicine 生物-工程：生物医学

CiteScore

7.50

自引率

3.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Journal of Tissue Engineering and Regenerative Medicine publishes rapidly and rigorously peer-reviewed research papers, reviews, clinical case reports, perspectives, and short communications on topics relevant to the development of therapeutic approaches which combine stem or progenitor cells, biomaterials and scaffolds, growth factors and other bioactive agents, and their respective constructs. All papers should deal with research that has a direct or potential impact on the development of novel clinical approaches for the regeneration or repair of tissues and organs. The journal is multidisciplinary, covering the combination of the principles of life sciences and engineering in efforts to advance medicine and clinical strategies. The journal focuses on the use of cells, materials, and biochemical/mechanical factors in the development of biological functional substitutes that restore, maintain, or improve tissue or organ function. The journal publishes research on any tissue or organ and covers all key aspects of the field, including the development of new biomaterials and processing of scaffolds; the use of different types of cells (mainly stem and progenitor cells) and their culture in specific bioreactors; studies in relevant animal models; and clinical trials in human patients performed under strict regulatory and ethical frameworks. Manuscripts describing the use of advanced methods for the characterization of engineered tissues are also of special interest to the journal readership.