Stereoselective Construction of (E,Z)‐1,3‐Dienes and Its Application in Natural Product Synthesis

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2020-12-01 DOI:10.1002/adsc.202000730

Pierre Hubert , Elena Seibel , Christine Beemelmanns , Jean‐Marc Campagne , Renata Marcia de Figueiredo

引用次数: 21

Abstract

The E,Z‐configured 1,3‐diene unit is a common motif in numerous bioactive natural products. Although several powerful methods are available to produce these motifs with high levels of selectivity, their construction within a complex, polyfunctionalised structure, such as a natural product, requires well‐defined strategies to avoid undesirable reactions and low‐to‐moderate selectivities. The aim of this review is to provide a full account of the stereoselective strategies for building E,Z‐configured 1,3‐dienes, as well as to highlight selected total syntheses that employ them.

Abstract Image

查看原文本刊更多论文

(E,Z)‐1,3‐二烯的立体选择性结构及其在天然产物合成中的应用

E,Z -构型1,3 -二烯单元是许多生物活性天然产物中的常见基序。虽然有几种有效的方法可以产生具有高选择性的这些基序，但它们在复杂的多功能化结构(如天然产物)中的构建需要明确的策略来避免不良反应和中低选择性。本综述的目的是全面介绍构建E,Z构型1,3二烯的立体选择策略，并重点介绍采用这些策略的全合成方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.