{"title":"Activity of the Fungicide JS399-19 Against Fusarium Head Blight of Wheat and the Risk of Resistance","authors":"Yu CHEN , Wen-xiang WANG , Ai-fang ZHANG , Chun-yan GU , Ming-guo ZHOU , Tong-chun GAO","doi":"10.1016/S1671-2927(11)60191-0","DOIUrl":null,"url":null,"abstract":"<div><h3>Abstract</h3><p>This report reviews the characteristics of JS399-19, a novel cyanoacrylate fungicide. JS399-19 strongly inhibits the mycelial growth of the fungal plant pathogens of the genus <em>Fusarium</em> and exhibits great potential in controlling Fusarium head blight (FHB) on wheat and other cereals. The mode of action of JS399-19 is evidently different from that of benzimidazole (for example, carbendazim) and other sort of fungicides, making it a possible replacement for carbendazim in China to manage carbendazim-resistant subpopulations of <em>Fusarium graminearum</em> and <em>F. asiaticum.</em> JS399-19 has excellent protective and curative activity against these pathogens. Incorrect use of this fungicide, however, is likely to select for resistance. Among JS399-19-resistant mutants of <em>F. asiaticum</em> induced in the laboratory, the resistant level of mutants was high and the phenotype of resistance against JS399-19 was conferred by a major gene by genetic analysis. The fitness of laboratory-induced JS399-19-resistant mutants of <em>F. asiaticum</em> was nearly equal to that of their parents. JS399-19 lacks cross resistance with other sort fungicides. To control FHB with JS399-19 and to delay the development of the fungicide-resistance, farmers should use tank mixtures containing JS399-19 and carbendazim, metconazole, tebuconazole, or prothioconazole.</p></div>","PeriodicalId":7475,"journal":{"name":"Agricultural Sciences in China","volume":"10 12","pages":"Pages 1906-1913"},"PeriodicalIF":0.0000,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1671-2927(11)60191-0","citationCount":"35","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Agricultural Sciences in China","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1671292711601910","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 35
Abstract
This report reviews the characteristics of JS399-19, a novel cyanoacrylate fungicide. JS399-19 strongly inhibits the mycelial growth of the fungal plant pathogens of the genus Fusarium and exhibits great potential in controlling Fusarium head blight (FHB) on wheat and other cereals. The mode of action of JS399-19 is evidently different from that of benzimidazole (for example, carbendazim) and other sort of fungicides, making it a possible replacement for carbendazim in China to manage carbendazim-resistant subpopulations of Fusarium graminearum and F. asiaticum. JS399-19 has excellent protective and curative activity against these pathogens. Incorrect use of this fungicide, however, is likely to select for resistance. Among JS399-19-resistant mutants of F. asiaticum induced in the laboratory, the resistant level of mutants was high and the phenotype of resistance against JS399-19 was conferred by a major gene by genetic analysis. The fitness of laboratory-induced JS399-19-resistant mutants of F. asiaticum was nearly equal to that of their parents. JS399-19 lacks cross resistance with other sort fungicides. To control FHB with JS399-19 and to delay the development of the fungicide-resistance, farmers should use tank mixtures containing JS399-19 and carbendazim, metconazole, tebuconazole, or prothioconazole.
摘要本文综述了新型氰基丙烯酸酯类杀菌剂JS399-19的特性。JS399-19对镰刀菌属植物真菌病原菌的菌丝生长有较强的抑制作用，在防治小麦和其他谷物的镰刀菌头疫病(Fusarium head blight, FHB)方面具有很大的潜力。JS399-19的作用方式与苯并咪唑(如多菌灵)等杀菌剂的作用方式有明显的不同，在中国有可能作为多菌灵的替代品来治理稻谷镰刀菌和亚洲镰刀菌的耐多菌灵亚群。JS399-19对这些病原菌具有良好的保护和治疗作用。然而，不正确地使用这种杀菌剂可能会选择耐药性。在实验室诱导的亚洲镰刀菌JS399-19抗性突变体中，抗性水平较高，遗传分析表明对JS399-19的抗性表型由一个主基因赋予。实验室诱导的亚洲镰刀菌js399 -19抗性突变体与其亲本的适应度基本相等。JS399-19与其他种类杀菌剂缺乏交叉抗性。为了用JS399-19控制FHB并延缓其产生抗药性，农民应使用含有JS399-19和多菌灵、甲康唑、替布康唑或原硫康唑的罐式混合物。
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