Sistema renina-angiotensina-aldosterona y COVID19. Implicaciones clínicas

Q4 Medicine
Pedro Caravaca Pérez , Laura Morán Fernández , María Dolores García-Cosio , Juan F. Delgado
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引用次数: 4

Abstract

The pandemic caused by the rapid spread of the SARS-CoV-2 virus has produced the greatest health crisis of modern times. The close relationship between the virus and angiotensin-II converting enzyme has provoked a torrent of speculation about the possible role of the renin-angiotensin-aldosterone system (RAAS) in mediating infection. The subsequent alarm has raised questions about the use of RAAS inhibitors, such as angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers. The result has been the publication of several studies that have failed to find an association between the use of RAAS inhibitors and greater susceptibility to infección or a worse clínical outlook. This review considers the most significant aspects of the interaction between SARS-CoV-2 and the RAAS and the clínical implications of using RAAS inhibitors during the pandemic.

肾素-血管紧张素-醛固酮系统与covid - 19。临床意义
由SARS-CoV-2病毒迅速传播引起的大流行造成了现代最大的健康危机。病毒与血管紧张素- ii转换酶之间的密切关系引发了关于肾素-血管紧张素-醛固酮系统(RAAS)在介导感染中的可能作用的大量猜测。随后的警报对RAAS抑制剂的使用提出了质疑,如血管紧张素转换酶抑制剂和血管紧张素- ii受体阻滞剂。结果是发表的几项研究未能发现使用RAAS抑制剂与infección或更差的clínical前景的更大易感性之间的关联。本综述考虑了SARS-CoV-2与RAAS之间相互作用的最重要方面,以及在大流行期间使用RAAS抑制剂的clínical影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Revista Espanola de Cardiologia Suplementos
Revista Espanola de Cardiologia Suplementos Medicine-Cardiology and Cardiovascular Medicine
CiteScore
1.20
自引率
0.00%
发文量
1
期刊介绍: Revista Española de Cardiología, is an international scientific journal dealing with cardiovascular medicine. Revista Española de Cardiología, the official publication of the Spanish Society of Cardiology, publishes research articles related to cardiovascular diseases. Articles are published in Spanish for the paper edition and in both Spanish and English in the electronic edition, which is available on the Internet. Regular sections include original articles reporting clinical or basic research, brief reports, review articles, editorials and letters to the Editor.
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