{"title":"Impact of HIV on the human gut microbiota: Challenges and perspectives","authors":"Grégory Dubourg","doi":"10.1016/j.humic.2016.10.001","DOIUrl":null,"url":null,"abstract":"<div><p>Interplay between the gut microbiota and the immune system during HIV infection is currently a subject of intense research. Several remarkable works were recently published and clearly associated structural changes in its composition with disease progression markers. As well, specific commensal species were reported to contribute to immune activation during the infection. However, the use of extremely varied material and methods has led to inconsistent findings, sometimes discrepant. Herein, we propose to review the main studies dedicated to the impact of HIV on the gut microbiota composition such as those deciphering interplay between gut bacterial species and the immune system during the infection. We finally provide exciting perspectives in modulating the HIV gut microbiome to lessen disease progression as a novel adjuvant treatment.</p></div>","PeriodicalId":37790,"journal":{"name":"Human Microbiome Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.humic.2016.10.001","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Microbiome Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452231716300173","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 9
Abstract
Interplay between the gut microbiota and the immune system during HIV infection is currently a subject of intense research. Several remarkable works were recently published and clearly associated structural changes in its composition with disease progression markers. As well, specific commensal species were reported to contribute to immune activation during the infection. However, the use of extremely varied material and methods has led to inconsistent findings, sometimes discrepant. Herein, we propose to review the main studies dedicated to the impact of HIV on the gut microbiota composition such as those deciphering interplay between gut bacterial species and the immune system during the infection. We finally provide exciting perspectives in modulating the HIV gut microbiome to lessen disease progression as a novel adjuvant treatment.
期刊介绍：
The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.
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