Can Electroacupuncture Be Useful in Opioid-Induced Hyperalgesia? A Case Report.

IF 0.9 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE
Marco Di Carlo, Antonio D'Addario, Fausto Salaffi
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Abstract

Opioid-induced hyperalgesia (OIH) is characterized by a paradoxical increase in pain sensitivity following opioid exposure. Although animal models indicate that electroacupuncture (EA) is effective against pain sensitization, there are no reports of its clinical application in OIH treatment. This case report involves an adult patient with osteomalacia complicated by multiple vertebral fragility fractures. The patient developed OIH following the use of oxycodone to treat severe disabling lower back pain that was refractory to nonsteroidal anti-inflammatory drugs. After hospitalization and treatment with low EA-frequency (2-10 Hz) sessions, the patient exhibited significant pain reduction and functional recovery after the first session, which was accompanied by steady progressive improvement as the treatment continued. This case report illustrates the clinical efficacy of EA in OIH treatment and indicates that EA, which has multiple modes of action on the neurobiology of chronic pain, has potential applications in the management of complex and difficult-to-manage conditions, such as OIH.

电针对阿片类药物引起的痛觉过敏有用吗?案例报告。
阿片诱导的痛觉过敏(OIH)的特征是阿片类药物暴露后疼痛敏感性的反常增加。尽管动物模型表明电针(EA)对疼痛致敏有效,但尚未有其在OIH治疗中的临床应用报告。本病例报告涉及一名患有骨软化症并伴有多发性脊椎脆性骨折的成年患者。患者在使用羟考酮治疗非甾体抗炎药难治的严重致残性下背痛后出现OIH。在住院治疗和低电针频率(2-10 Hz)治疗后,患者在第一次治疗后表现出显著的疼痛减轻和功能恢复,随着治疗的继续,疼痛和功能逐渐改善。该病例报告说明了电针在OIH治疗中的临床疗效,并表明电针对慢性疼痛的神经生物学具有多种作用模式,在管理复杂和难以管理的疾病(如OIH)方面具有潜在应用。
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来源期刊
Journal of Acupuncture and Meridian Studies
Journal of Acupuncture and Meridian Studies INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
1.50
自引率
10.00%
发文量
35
审稿时长
12 weeks
期刊介绍: The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine. Manuscripts should fall into one of the categories: topical review, original research paper, brief ... click here for full Aims & Scope The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine.
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