Fabrication of glycidyl methacrylate-modified silk fibroin/poly(L-lactic acid-co-ε-caprolactone)–polyethylene glycol diacrylate hybrid 3D nanofibrous scaffolds for tissue engineering

IF 2.5 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Frontiers of Materials Science Pub Date : 2023-05-26 DOI:10.1007/s11706-023-0647-7

Yongyong Fan, Anlin Yin, Yunhuan Li, Qi Gu, Yan Zhou, Junlong Zhou, Ruibo Zhao, Kuihua Zhang

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引用次数: 1

Abstract

In order to provide a biomimetic natural extracellular matrix microenvironment with excellent mechanical capacity for tissue regeneration, a novel porous hybrid glycidyl methacrylate-modified silk fibroin/poly(L-lactic acid-ε-caprolactone)-polyethylene glycol diacrylate (SFMA/P(LLA-CL)-PEGDA) hybrid three-dimensional (3D) nanofibrous scaffolds was successfully fabricated through the combination of 3D nanofibrous platforms and divinyl PEGDA based photocrosslinking, and then further improved water resistance by ethanol vapor post-treatment. Scanning electron microscopy and micro-computed tomography results demonstrated significant PEGDA hydrogel-like matrices bonded nanofibers, which formed a 3D structure similar to that of “steel bar (nanofibers)–cement (PEGDA)”, with proper pore size, high porosity, and high pore connectivity density. Meanwhile, the hybrid 3D nanofibrous scaffolds showed outstanding swelling properties as well as improved compressive and tensile properties. Furthermore, these hybrid 3D nanofibrous scaffolds could provide a biocompatible microenvironment, capable of inducing the material–cell hybrid and regulating human umbilical vein endothelial cells proliferation. They thus present significant potential in tissue regeneration.

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甲基丙烯酸缩水甘油酯-改性丝素/聚(l -乳酸-co-ε-己内酯)-聚乙二醇二丙烯酸酯杂化三维纳米纤维支架的制备

为了提供具有良好组织再生力学性能的仿生天然细胞外基质微环境，通过将三维纳米纤维平台与二乙烯基PEGDA光交联相结合，成功制备了新型多孔甲基丙烯酸甘油酯改性丝素/聚l -乳酸-ε-己内酯-聚乙二醇二丙烯酸酯(SFMA/P(la - cl)-PEGDA)杂化三维(3D)纳米纤维支架。再通过乙醇蒸汽后处理进一步提高其耐水性。扫描电镜和微计算机断层扫描结果显示，纳米纤维与PEGDA水凝胶状基质结合，形成类似于“钢筋(纳米纤维)-水泥(PEGDA)”的三维结构，孔径合适，孔隙率高，孔隙连通密度高。同时，复合三维纳米纤维支架具有良好的溶胀性能和较好的抗压、拉伸性能。此外，这些复合三维纳米纤维支架可以提供一个生物相容性微环境，能够诱导材料-细胞杂交并调节人脐静脉内皮细胞的增殖。因此，它们在组织再生方面具有显著的潜力。

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来源期刊

Frontiers of Materials Science MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

4.20

自引率

3.70%

发文量

515

期刊介绍： Frontiers of Materials Science is a peer-reviewed international journal that publishes high quality reviews/mini-reviews, full-length research papers, and short Communications recording the latest pioneering studies on all aspects of materials science. It aims at providing a forum to promote communication and exchange between scientists in the worldwide materials science community. The subjects are seen from international and interdisciplinary perspectives covering areas including (but not limited to): Biomaterials including biomimetics and biomineralization; Nano materials; Polymers and composites; New metallic materials; Advanced ceramics; Materials modeling and computation; Frontier materials synthesis and characterization; Novel methods for materials manufacturing; Materials performance; Materials applications in energy, information and biotechnology.