Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque québécoise de la COVID-19 (BQC-19).

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Eric Yamga, Antoine Soulé, Alain Piché, Amin Emad, Madeleine Durand, Simon Rousseau
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引用次数: 0

Abstract

The quest for understanding and managing the long-term effects of COVID-19, often referred to as Long COVID or post-COVID-19 condition (PCC), remains an active research area. Recent findings highlighted angiopoietin-1 (ANG-1) and p-selectin (P-SEL) as potential diagnostic markers, but validation is essential, given the inconsistency in COVID-19 biomarker studies. Leveraging the biobanque québécoise de la COVID-19 (BQC19) biobank, we analyzed the data of 249 participants. Both ANG-1 and P-SEL levels were significantly higher in patients with PCC participants compared with control subjects at 3 months using the Mann-Whitney U test. We managed to reproduce and validate the findings, emphasizing the importance of collaborative biobanking efforts in enhancing the reproducibility and credibility of Long COVID research outcomes.

Abstract Image

使用来自COVID-19生物样本(BQC-19)的数据验证ANG-1和P-SEL作为COVID-19后疾病的生物标志物。
寻求理解和管理新冠肺炎的长期影响,通常被称为长期新冠肺炎或新冠肺炎后疾病(PCC),仍然是一个活跃的研究领域。最近的研究结果强调血管生成素-1(ANG-1)和p-选择素(p-SEL)是潜在的诊断标志物,但鉴于新冠肺炎生物标志物研究的不一致性,验证是必不可少的。利用新冠肺炎生物库(BQC19),我们分析了249名参与者的数据。在使用Mann-Whitney U检验的3个月时,PCC参与者患者的ANG-1和P-SEL水平均显著高于对照受试者。我们成功地复制和验证了这些发现,强调了合作生物库工作在提高Long COVID研究结果的可重复性和可信度方面的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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