Oncolytic viral therapy as promising immunotherapy against glioma

Die Hu, Yaomei Tian, Jie Xu, Daoyuan Xie, Yusi Wang, Mohan Liu, Yuanda Wang, Li Yang
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Abstract

Glioma is a common primary central nervous system malignant tumor in clinical, traditional methods such as surgery and chemoradiotherapy are not effective in treatment. Therefore, more effective treatments need to be found. Oncolytic viruses (OVs) are a new type of immunotherapy that selectively infects and kills tumor cells instead of normal cells. OVs can mediate antitumor immune responses through a variety of mechanisms, and have the ability to activate antitumor immune responses, transform the tumor microenvironment from “cold” to “hot,” and enhance the efficacy of immune checkpoint inhibitors. Recently, a large number of preclinical and clinical studies have shown that OVs show great prospects in the treatment of gliomas. In this review, we summarize the current status of glioma therapies with a focus on OVs. First, this article introduces the current status of treatment of glioma and their respective shortcomings. Then, the important progress of OVs of in clinical trials of glioma is summarized. Finally, the urgent challenges of oncolytic virus treatment for glioma are sorted out, and related solutions are proposed. This review will help to further promote the use of OVs in the treatment of glioma.

Abstract Image

溶瘤病毒治疗是一种有前景的神经胶质瘤免疫疗法
胶质瘤是临床上常见的原发性中枢神经系统恶性肿瘤,传统的手术、放化疗等方法治疗效果不佳。因此,需要找到更有效的治疗方法。溶瘤病毒(OVs)是一种新型的免疫疗法,它选择性地感染和杀死肿瘤细胞,而不是正常细胞。OVs可以通过多种机制介导抗肿瘤免疫反应,并具有激活抗肿瘤免疫应答的能力,将肿瘤微环境从“冷”转变为“热”,并增强免疫检查点抑制剂的功效。近年来,大量临床前和临床研究表明,OVs在治疗胶质瘤方面显示出巨大的前景。在这篇综述中,我们总结了神经胶质瘤治疗的现状,重点是OVs。本文首先介绍了胶质瘤的治疗现状及其各自的不足。综述了OVs在胶质瘤临床试验中的重要进展。最后,对溶瘤病毒治疗胶质瘤的紧迫挑战进行了梳理,并提出了相关的解决方案。这篇综述将有助于进一步促进OVs在神经胶质瘤治疗中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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