Evaluation of von Willebrand factor and protein/creatinine ratio in idiopathic sudden hearing loss

IF 0.9 Q3 OTORHINOLARYNGOLOGY

Acta otorrinolaringologica espanola Pub Date : 2023-09-01 DOI:10.1016/j.otorri.2022.09.002

Özge Çaglar Çil , Serkan Bakirdögen , Dilek Ülker Çakir , Hasan Gül , Sibel Oymak

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引用次数: 0

Abstract

Objective

The objective of this study was to evaluate the levels of von Willebraund Factor (vWF) in plasma and the protein/creatinine ratio in urine in patients with idiopathic sudden acute hearing loss, which we think to be caused by epithelial dysfunction.

Materials-Methods

Thirty patients with a sudden hearing loss and thirty healthy individuals were included in the study. Before the treatment, blood and urine were collected from the patients and the control group to investigate the levels of the protein/creatinine ratio and the levels of vWF. The test results of the patients group were compared with those of the control group.

Results

We found that the levels of vWF increased in the patient group, which was statistically significant (P < .05). The protein/creatinine ratio in the urine increased in the patient group, but this was not statistically significant (P > .05). In addition, we found that the vWF and urine protein/creatin ratio of the patients who benefited from treatment were lower than those who did not benefit.

Conclusions

This study showed that sudden sensorineural hearing loss may result from endothelial dysfunction. However, more studies that include more patients are needed in order to support this.

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特发性突发性听力损失中血管性血友病因子和蛋白/肌酐比值的评价

目的评价特发性突发性急性听力损失患者血浆血管性血友病因子(vWF)水平和尿蛋白/肌酐比值，我们认为这是上皮功能障碍引起的。材料-方法选取30例突发性听力损失患者和30例健康人作为研究对象。治疗前分别采集患者和对照组的血、尿，检测蛋白/肌酐比值和vWF水平。将患者组的检测结果与对照组进行比较。结果患者组vWF水平升高，差异有统计学意义(P <.05）. 患者组尿中蛋白/肌酐比值升高，但无统计学意义(P >.05）. 此外，我们发现受益于治疗的患者的vWF和尿蛋白/生成比低于未受益的患者。结论突发性感音神经性听力损失可能由内皮功能障碍引起。然而，为了支持这一点，需要更多的研究，包括更多的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta otorrinolaringologica espanola OTORHINOLARYNGOLOGY-

CiteScore

1.40

自引率

20.00%

发文量

审稿时长

44 days

期刊介绍： Es la revista más importante en español dedicada a la especialidad. Ofrece progresos científicos y técnicos tanto a nivel de originales como de casos clínicos. Además, es la Publicación Oficial de la Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial y está presente en los más prestigiosos índices de referencia.