Versatile dual responsive EGCG/Cys nano delivery system for atherosclerosis

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications Pub Date : 2023-07-01 DOI:10.1016/j.colcom.2023.100725

Xin Li , Chunbin Wang , Lei Zhou , Lu Zhang , Jin Li , Shuang Lin , Xiuqiong Yu , Jun Hou , Shiqiang Xiong , Yuancong Zhao , Lin Cai , Hanxiong Liu , Zhen Zhang , Jin Wang

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Abstract

Nanocarriers receive tremendous attention in nanomedicine and precision biomedicine, especially cardiovascular diseases. However, the ideal carriers for multiple agents are still got a long way to come. In this work, one REDOX dual responsive nanoparticle was designed and constructed by epigallocatechin gallate (EGCG) and cystamine (Cys). The particles presented uniform sphere, and its diameter was around 200 nm. The drug loading ability of the particles was evaluated using rhodamine 6G (Rh6G), rapamycin (Rapa) and bovine serum albumin as model drugs. The EGCG/Cys particles could intelligently release drugs based on the REDOX level of local environment. The morphology and cell viability results of endothelial cells (ECs) and macrophage cells verified the good biocompatibility of the particles. The biosecurity of the particles was further confirmed by injections in vivo. Moreover, the EGCG/Cys particles could effectively target the injured vascular. These results confirmed that the EGCG/Cys particles could be used as one universal carrier to build nano delivery system for drugs, biological agent and vaccines for targeted treatment of atherosclerosis. The work provides one novel promising universal nanocarrier with good bio-safety for multiple drugs and bio-agents for atherosclerosis treatment.

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用于动脉粥样硬化的多功能双响应EGCG/Cys纳米递送系统

纳米载体在纳米医学和精密生物医学，特别是心血管疾病中受到极大关注。然而，多个代理的理想载体还有很长的路要走。在本工作中，设计并构建了一种由表没食子儿茶素没食子酸盐（EGCG）和胱胺（Cys）组成的REDOX双反应纳米颗粒。颗粒呈均匀球形，直径约为200nm。以罗丹明6G（Rh6G）、雷帕霉素（Rapa）和牛血清白蛋白为模型药物，评价了颗粒的载药能力。EGCG/Cys颗粒可以根据局部环境的氧化还原水平智能地释放药物。内皮细胞（EC）和巨噬细胞的形态学和细胞活力结果证实了颗粒具有良好的生物相容性。通过体内注射进一步证实了颗粒的生物安全性。此外，EGCG/Cys颗粒可以有效地靶向损伤的血管。这些结果证实，EGCG/Cys颗粒可以作为一种通用载体，构建用于靶向治疗动脉粥样硬化的药物、生物制剂和疫苗的纳米递送系统。该工作为多种药物和生物制剂治疗动脉粥样硬化提供了一种具有良好生物安全性的新型通用纳米载体。

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来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.