Low UPB1 Level Correlates With Poor Prognosis in Lung Adenocarcinoma.

IF 1.3 4区医学 Q3 ANATOMY & MORPHOLOGY

Applied Immunohistochemistry & Molecular Morphology Pub Date : 2024-01-01 Epub Date: 2023-10-20 DOI:10.1097/PAI.0000000000001159

Libin Zhang, Jun Liu, Han Wang, Zheyuan Xu, Yang Wang, Yun Chen, Hao Peng

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引用次数: 0

Abstract

Objectives: Lung adenocarcinoma (LUAD) is a critical cancer with high mortality, worse prognosis, and crucial lymphatic metastasis. Consequently, prognostic biomarkers for LUAD are truly required. β-Ureidopropionase (UPB1) is abnormally expressed in various cancers. However, the function of UPB1 in LUAD is still ambiguous. This study aimed to explore the expression profile and prognostic significance of UPB1 in LUAD.

Materials and methods: The differential UPB1 levels in pan cancers and their prognostic significance were comprehensively investigated through Gene Expression Profiling Interactive Analysis, UALCAN, Tumor Immune Estimation Resource, and Kaplan-Meier plotter platform. The correlation between UPB1 and tumor infiltration immune cells was explored using Tumor Immune Estimation Resource, Gene Expression Profiling Interactive Analysis, and Tumor-Immune System Interactions and Drug Bank database databases.

Results: The UPB1 level was abnormally expressed in pan-tumor tissue than in adjacent tissue from The Cancer Genome Atlas tool. Low UPB1 level was correlated with poor overall survival in patients with LUAD. Furthermore, a comparison of the various pathologic characteristics of LUAD between high and low UPB1 level subgroups revealed that low UPB1 expression was correlated with lymph node metastasis. Kaplan-Meier survival analysis indicated that a low UPB1 level was associated with worse progression‑free survival and overall survival in patients with LUAD. Univariate and multivariate analyses suggested that UPB1 could be a useful prognostic indicator for LUAD. Abnormal UPB1 may be correlated with aberrant LUAD immune infiltration, prompting a worse survival outcome.

Conclusions: Results showed that low UPB1 is correlated with a worse prognosis of LUAD and may be a valuable prognostic indicator for LUAD.

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低UPB1水平与肺腺癌预后不良相关。

目的：肺腺癌（LUAD）是一种死亡率高、预后差、淋巴结转移严重的癌症。因此，LUAD的预后生物标志物是真正需要的。β-尿苷丙酸酶（UPB1）在各种癌症中异常表达。然而，UPB1在LUAD中的作用仍然不明确。本研究旨在探讨UPB1在LUAD中的表达谱和预后意义。材料和方法：通过基因表达谱交互分析、UALCAN、肿瘤免疫评估资源和Kaplan-Meier绘图平台，全面研究UPB1在泛癌中的差异水平及其预后意义。利用肿瘤免疫评估资源、基因表达谱交互分析、肿瘤免疫系统相互作用和药物库数据库探讨了UPB1与肿瘤浸润免疫细胞之间的相关性。结果：来自癌症基因组图谱工具的UPB1水平在全肿瘤组织中比在邻近组织中异常表达。LUAD患者UPB1水平低与总生存率低相关。此外，对高和低UPB1水平亚组LUAD的各种病理特征的比较表明，低UPB1表达与淋巴结转移相关。Kaplan-Meier生存率分析表明，低UPB1水平与LUAD患者的无进展生存率和总生存率较差有关。单因素和多因素分析表明，UPB1可能是LUAD的有用预后指标。异常的UPB1可能与异常的LUAD免疫浸润有关，从而导致更差的生存结果。结论：结果表明，低UPB1与LUAD的预后较差相关，可能是LUAD的一个有价值的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY

CiteScore

3.20

自引率

0.00%

发文量

153

期刊介绍： Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology.