Associations of semen quality with pyrethroids in semen and urine samples of men with oligozoospermia: A cross-sectional study in Samsun, Turkey.

IF 1.7 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Toxicology and Industrial Health Pub Date : 2023-12-01 Epub Date: 2023-10-20 DOI:10.1177/07482337231209356

Murat Alagöz, Selma Yazar, Hale Secilmis Canbay, Abdullah Acıkgöz, Burcin S Corba

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引用次数: 0

Abstract

Pyrethroids (PYRs) may act as endocrine disrupters and lead to infertility. The aim of the study was to analyze the levels of anti-androgenic PYRs (cypermethrin, deltamethrin, and permethrin) and 3-phenoxy benzoic acid (3-PBA), a general metabolite of PYRs, in both semen and urine samples of men with oligozoospermia. The PYRs and 3-PBA metabolite levels in the semen and urine samples of the men were analyzed through GC-MS. The results indicated that the levels of PYRs in the semen samples of the infertile group were significantly higher than those of the fertile group. It was determined that cypermethrin exposure was associated with changes in sperm count and total sperm motility, while permethrin, deltamethrin, and 3-PBA levels were associated with changes in sperm morphology. It was determined that there was a significant negative correlation between semen deltamethrin levels and sperm morphology and sperm count. In addition, exposure of these patients to deltamethrin (range; 1.53-8.02 µg/l) and having farmer parents were determined to increase the risk of infertility. In conclusion, the findings of this study showed that exposure to environmental PYRs may adversely affect semen quality, especially in terms of sperm morphology, in men with oligozoospermia.

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少精症男性精液和尿液样本中拟除虫菊酯类与精液质量的关系：土耳其萨姆森的一项横断面研究。

拟除虫菊酯类（PYRs）可能作为内分泌干扰物，导致不孕。本研究的目的是分析少精症男性精液和尿液样本中抗雄性PYRs（氯氰菊酯、溴氰菊酯和氯氰菊酯）和PYRs的一般代谢产物3-苯氧基苯甲酸（3-PBA）的水平。通过气相色谱-质谱联用技术分析了男性精液和尿液中PYRs和3-PBA代谢产物的水平。结果表明，不育组精液样本中PYRs水平显著高于可育组。经测定，氯氰菊酯暴露与精子数量和精子总活力的变化有关，而氯氰菊酯、溴氰菊酯和3-BA水平与精子形态的变化有关。精液中溴氰菊酯含量与精子形态和精子数量呈显著负相关。此外，这些患者暴露于溴氰菊酯（范围：1.53-8.02µg/l）和有农民父母被确定会增加不孕风险。总之，这项研究的结果表明，暴露于环境PYR可能会对少精症男性的精液质量产生不利影响，尤其是在精子形态方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicology and Industrial Health 医学-毒理学

CiteScore

3.50

自引率

5.30%

发文量

审稿时长

4 months

期刊介绍： Toxicology & Industrial Health is a journal dedicated to reporting results of basic and applied toxicological research with direct application to industrial/occupational health. Such research includes the fields of genetic and cellular toxicology and risk assessment associated with hazardous wastes and groundwater.