{"title":"One Health Lens for Antimicrobial Resistance Research and Funding: A Systematic Review.","authors":"Issam Alsamara, Lesley Ogilvie, Ralf Sudbrak, Angela Brand","doi":"10.1089/omi.2023.0049","DOIUrl":null,"url":null,"abstract":"<p><p>One Health (OH) offers conceptual and applied prospects to advance planetary health and integrative biology in the 21st century. For example, The World Health Organization (WHO) has declared antimicrobial resistance (AMR) one of humanity's top 10 health threats worldwide (AMR). The AMR research, as seen through the OH lens, recognizes the interdependence and the coproduction of the health of humans, nonhuman animals, and the environment (the OH triad). Moreover, research and development (R&D) is required to generate potential solutions to prevent, diagnose, and treat infections and control the spread and emergence of AMR. However, it is still unclear how well the OH approach is integrated into current AMR R&D. In this study, we present a systematic review on the OH funding landscape for cross-sectoral AMR R&D, and its alignment/gaps with the current global strategic agenda on AMR. A systematic literature review was conducted using public databases covering the period between January 2015 and May 2022. We included the studies and reviews on AMR encompassing more than one sector of the OH triad. Out of the 777 included studies, 475 (61%) encompassed the three OH sectors. A key finding of the present systematic review is that the environment was the most neglected sector in the OH triad. AMR surveillance, transmission, and interventions are the most commonly studied priority topics. In addition, both cross-sectoral AMR literature and investments have been increasing since 2017. The operational aspect of AMR is the most researched and funded area. However, certain priority topics in the strategic research and innovation agenda of the Joint Programming Initiative on AMR are underrepresented in OH AMR research, such as diagnosis and therapeutics. To the best of authors' knowledge, this is the first study that systematically reviews the cross-sectoral literature on AMR, classifies it, and aligns and contextualizes it in regard to the funding landscape of AMR. This systematic review identifies neglected areas in AMR R&D and could serve as critical information for policymaking so as to realize the objectives of the Global Action Plan on AMR. Going forward, more cross-sectoral AMR research and funding are needed. As integrative biology and omics systems science are poised to benefit from a rapprochement with the OH lens, the present article highlights the AMR research and funding landscapes.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1089/omi.2023.0049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
One Health (OH) offers conceptual and applied prospects to advance planetary health and integrative biology in the 21st century. For example, The World Health Organization (WHO) has declared antimicrobial resistance (AMR) one of humanity's top 10 health threats worldwide (AMR). The AMR research, as seen through the OH lens, recognizes the interdependence and the coproduction of the health of humans, nonhuman animals, and the environment (the OH triad). Moreover, research and development (R&D) is required to generate potential solutions to prevent, diagnose, and treat infections and control the spread and emergence of AMR. However, it is still unclear how well the OH approach is integrated into current AMR R&D. In this study, we present a systematic review on the OH funding landscape for cross-sectoral AMR R&D, and its alignment/gaps with the current global strategic agenda on AMR. A systematic literature review was conducted using public databases covering the period between January 2015 and May 2022. We included the studies and reviews on AMR encompassing more than one sector of the OH triad. Out of the 777 included studies, 475 (61%) encompassed the three OH sectors. A key finding of the present systematic review is that the environment was the most neglected sector in the OH triad. AMR surveillance, transmission, and interventions are the most commonly studied priority topics. In addition, both cross-sectoral AMR literature and investments have been increasing since 2017. The operational aspect of AMR is the most researched and funded area. However, certain priority topics in the strategic research and innovation agenda of the Joint Programming Initiative on AMR are underrepresented in OH AMR research, such as diagnosis and therapeutics. To the best of authors' knowledge, this is the first study that systematically reviews the cross-sectoral literature on AMR, classifies it, and aligns and contextualizes it in regard to the funding landscape of AMR. This systematic review identifies neglected areas in AMR R&D and could serve as critical information for policymaking so as to realize the objectives of the Global Action Plan on AMR. Going forward, more cross-sectoral AMR research and funding are needed. As integrative biology and omics systems science are poised to benefit from a rapprochement with the OH lens, the present article highlights the AMR research and funding landscapes.
One Health(OH)为推进21世纪的行星健康和综合生物学提供了概念和应用前景。例如,世界卫生组织(世界卫生组织)已宣布抗微生物耐药性(AMR)为全世界十大健康威胁之一。从OH的角度来看,AMR研究认识到了人类、非人类动物和环境健康的相互依存和共同生产(OH三元)。此外,还需要研发(R&D)来产生潜在的解决方案,以预防、诊断和治疗感染,并控制AMR的传播和出现。然而,目前尚不清楚OH方法在当前AMR研发中的整合程度。在这项研究中,我们对跨部门AMR研发的OH资金格局及其与当前全球AMR战略议程的一致性/差距进行了系统审查。使用公共数据库对2015年1月至2022年5月期间的文献进行了系统综述。我们纳入了AMR的研究和综述,包括OH三联体的一个以上部分。在777项纳入的研究中,475项(61%)涉及三个OH部门。本系统综述的一个关键发现是,环境是OH三元结构中最被忽视的部门。AMR监测、传播和干预是最常研究的优先课题。此外,自2017年以来,跨部门AMR文献和投资都在增加。AMR的运营方面是研究和资金最多的领域。然而,AMR联合规划倡议战略研究和创新议程中的某些优先主题在OH AMR研究中的代表性不足,如诊断和治疗。据作者所知,这是第一项系统回顾AMR跨部门文献的研究,对其进行了分类,并将其与AMR的资金环境相结合。这一系统审查确定了AMR研发中被忽视的领域,可作为决策的关键信息,以实现《全球AMR行动计划》的目标。展望未来,需要更多的跨部门AMR研究和资金。随着综合生物学和组学系统科学准备从与OH透镜的和解中受益,本文重点介绍了AMR的研究和资助情况。