Sachin Ranjan, Shalini Trivedi, Shruti Sharma, Salman Khan, Rakesh Pandey
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引用次数: 0
Abstract
The transmission of acetylcholine (ACh) is critically important for memory, learning, and behaviour. The most promising approaches for the treatment of cholinergic dysfunction involve the enhancement of ACh via nootropic phytomolecules. In the same line, the present study identifies the active molecule Bakuchiol derived from Psoralea corylifolia. Bakuchiol demonstrated significant elevation of ACh transmission, reduction of reactive oxygen species (ROS) levels, and extension of lifespan. Further investigation indicated that modulation of mRNA expression of genes encoding choline transporter, choline acetyltransferase, and acetylcholine transporter as possible effectors of amassed neural transmission. Moreover, Bakuchiol showed efficacy in reducing amyloid β and lipid levels, possibly through the upregulation of heat shock transcription factor 1 (hsf-1) and autophagy (lgg-1) genes. Overall, our findings establish the efficacy of Bakuchiol in modulating cholinergic dysfunction.
期刊介绍:
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.